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The Skinny on Dermal Fat and Its Anti-Inflammatory Role in Psoriasis.
J Invest Dermatol
September 2024
Department of Dermatology, University of California, Davis, Davis, California, USA; Department of Biomedical Engineering, University of California, Davis, Davis, California, USA. Electronic address:
Skinny Fat Cells Stimulate Wound Healing.
Cell Stem Cell
June 2020
Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:
In this issue of Cell Stem Cell, Shook et al. (2020) reveal that dermal adipocytes regulate skin wound repair via release of fatty acids that promote macrophage recruitment and accelerated revascularization. Furthermore, mature dermal adipocytes dedifferentiate into migratory extracellularmatrix-producing myofibroblasts.
View Article and Find Full Text PDFAcyltransferase skinny hedgehog regulates TGFβ-dependent fibroblast activation in SSc.
Ann Rheum Dis
September 2019
Department of Internal Medicine 3- Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany
Objectives: Systemic sclerosis (SSc) is characterised by aberrant hedgehog signalling in fibrotic tissues. The hedgehog acyltransferase (HHAT) skinny hedgehog catalyses the attachment of palmitate onto sonic hedgehog (SHH). Palmitoylation of SHH is required for multimerisation of SHH proteins, which is thought to promote long-range, endocrine hedgehog signalling.
View Article and Find Full Text PDFEvaluation of Gene Expression Patterns in Micrografts Demonstrate Induction of Catagen-Like Processes During Storage.
Dermatol Surg
February 2017
*All authors are affiliated with the Department for Hair Research, Moser Medical Group, Clinic Vienna, Austria.
Background: Alterations of gene expression patterns may contribute to the commonly observed transient reduction of hair shaft elongation in hair restoration surgery.
Objective: To elucidate the molecular causes, we evaluated changes in gene expression patterns in hair follicle micrografts during storage.
Materials And Methods: Micrografts with different amounts of adjacent connective tissue (regular, skinny, and chubby) were stored for different periods, and the expression of key genes was determined: dermal papilla (DP): FGF7, alkaline phosphatase (ALP), versican; outer root sheath: Krt15; inner root sheath: Krt 25; cuticula: Krt85; Henle layer: filaggrin; genes related to apoptosis and growth/differentiation: Caspase 3, Ovol1, and Foxo1.
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