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Imbalanced VWF-ADAMTS13 axis contributes to the detrimental impact of a preceding respiratory tract infection on stroke.
Blood Adv
January 2025
University of Iowa, Iowa city, Iowa, United States.
Respiratory tract infections (RTIs) caused by bacteria or viruses are associated with stroke severity. Recent studies have revealed an imbalance in the von Willebrand factor (VWF)-ADAMTS13 axis in patients with RTIs, including COVID-19. We examined whether this imbalance contributes to RTI-mediated stroke severity.
View Article and Find Full Text PDFvWF-ADAMTS13 axis in acute pancreatitis: Unveiling the hidden player or a mere bystander?
Pancreatology
November 2024
John Hopkins University, Baltimore, USA. Electronic address:
Von Willebrand factor exacerbates heart failure through formation of neutrophil extracellular traps.
Eur Heart J
October 2024
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Background And Aims: Heart failure (HF) is a leading cause of mortality worldwide and characterized by significant co-morbidities and dismal prognosis. Neutrophil extracellular traps (NETs) aggravate inflammation in various cardiovascular diseases; however, their function and mechanism of action in HF pathogenesis remain underexplored. This study aimed to investigate the involvement of a novel VWF-SLC44A2-NET axis in HF progression.
View Article and Find Full Text PDFCaplacizumab in pediatric immune thrombotic thrombocytopenic purpura: the UK TTP Registry experience.
Blood Adv
September 2024
Department of Haematology, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom.
Pediatric thrombotic thrombocytopenic purpura (TTP) is an ultrarare disease. Immune TTP (iTTP) is driven by anti-ADAMTS13 autoantibodies causing an imbalanced von Willebrand factor (VWF):ADAMTS13 axis, and rarer still in children, but potentially life-threatening. Caplacizumab is licensed for iTTP treatment in adults and adolescents aged ≥12 years who weigh ≥40 kg.
View Article and Find Full Text PDFImbalance in the vWF - ADAMTS13 axis exists early in acute pancreatitis and predicts persistent organ failure and pancreatic necrosis-a prospective study.
Pancreatology
November 2024
Departments of Gastroenterology, Christian Medical College, Vellore, Tamilnadu, 632517, India. Electronic address:
Background: The pathophysiology of Acute Pancreatitis (AP) may be complicated by endothelial activation. von Willebrand Factor (vWF)- ADAMTS13 axis is a marker of endothelial activation. The study aimed to investigate the axis in AP, comparing it in patients with and without persistent organ failure (OF), with and without pancreatic necrosis, and correlating it with the standard severity scores (CRP, APACHE II, BISAP, SOFA, and qSOFA) METHODS: vWF-Antigen (vWF:Ag), vWF-Collagen-Binding-Assay (vWF:CBA), and ADAMTS13 activity (ADAMTS13:act) levels were measured within 5 days of symptom onset in consecutive patients (n = 98), who were admitted with a first episode of AP (Dec 2021-May 2023).
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