AI Article Synopsis
- Over 100 autoimmune diseases affect about 20% of people in developed countries, especially women.
- Prolactin (PRL) is a hormone made in the pituitary gland that plays a big role in both the immune system and other body functions.
- Understanding how PRL can help or hurt the immune system is important for finding new ways to treat autoimmune diseases.
Article Abstract
Over 100 diseases have been recognized as autoimmune in nature, collectively affecting ∼20 % of the population in industrialized countries. These conditions are more prevalent among women of childbearing age, reflecting the potential association between alterations in the immune-neuroendocrine network, on the one hand, and autoimmune conditions, on the other. Prolactin (PRL), a polypeptide hormone that is primarily (but not only) secreted by the lactotrophic cells of the pituitary gland, is a critical element of the immune-neuroendocrine network. Although this hormone has several nonimmune functions, its role in regulating immune responses and affecting autoimmune inflammation is particularly enigmatic and controversial. Indeed, PRL interacts with various immune cells to bolster the body defenses, but also potentially to exacerbate autoimmune conditions. Understanding how and when PRL acts as a 'friend or foe' is crucial for unraveling its role as a potential therapeutic target in the management of autoimmune diseases (AIDs). This review therefore provides a critical overview of PRL's role in the immune system, and of the influence of this pleiotropic hormone in the development of autoimmunity.
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| http://dx.doi.org/10.1016/j.autrev.2024.103643 | DOI Listing |
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Article Synopsis
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- Prolactin (PRL) is a hormone made in the pituitary gland that plays a big role in both the immune system and other body functions.
- Understanding how PRL can help or hurt the immune system is important for finding new ways to treat autoimmune diseases.
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