AI Article Synopsis
- Sabia schumanniana Diels is a traditional plant used to treat back pain and joint pain, but research on its medicinal effects has been limited.
- The study focused on identifying anti-inflammatory compounds in this plant using advanced screening methods and molecular analysis.
- Seventeen compounds were identified, with N-nornuciferine showing significant anti-inflammatory properties, suggesting potential clinical applications for this traditional botanical.
Article Abstract
Ethnopharmacological Relevance: Sabia schumanniana Diels is a traditional botanical used to treat lumbago and arthralgia. However, there has been limited research on the pharmacological effects of its chemical components.
Aim Of The Study: This study aimed to rapidly screen for anti-inflammatory compounds in Sabia schumanniana Diels.
Materials And Methods: An affinity ultrafiltration method based on UHPLC-Q-Exactive Orbitrap MS was established to rapidly screen and identify cyclooxygenase-2 (COX-2) receptor ligands. The reliability of this method was verified by molecular docking analysis and experiments with RAW264.7 cells.
Results: Seventeen ligands were identified from Sabia schumanniana Diels using affinity ultrafiltration. Molecular docking results indicated that these ligands specifically docked with COX-2. Among them, N-nornuciferine exhibited notable anti-inflammatory activity.
Conclusions: The combination of affinity ultrafiltration and UHPLC-Q-Exactive Orbitrap MS is an effective and precise method for screening anti-inflammatory compounds. This study provides a foundation for further research on Sabia schumanniana Diels and offers guidance for its potential clinical applications.
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| http://dx.doi.org/10.1016/j.jep.2024.118845 | DOI Listing |
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Screening of anti-inflammatory active components in Sabia schumanniana Diels by affinity ultrafiltration and UHPLC-Q-Exactive Orbitrap mass spectrometry.
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Article Synopsis
- Sabia schumanniana Diels is a traditional plant used to treat back pain and joint pain, but research on its medicinal effects has been limited.
- The study focused on identifying anti-inflammatory compounds in this plant using advanced screening methods and molecular analysis.
- Seventeen compounds were identified, with N-nornuciferine showing significant anti-inflammatory properties, suggesting potential clinical applications for this traditional botanical.
A Systematic Method for the Identification of Aporphine Alkaloid Constituents in Sabia schumanniana Diels Using UHPLC-Q-Exactive Orbitrap/Mass Spectrometry.
Molecules
November 2022
School of Pharmacy, Weifang Medical University, Weifang 261000, China.
Diels (SSD) is a plant whose stems are used in traditional folk medicine for the treatment of lumbago and arthralgia. Previous studies have revealed chemical constituents of SSD, including triterpenoids and aporphine alkaloids. Aporphine alkaloids contain a variety of active components, which might facilitate the effective treatment of lumbago and arthralgia.
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