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Background: Ankylosing spondylitis (AS) is an inflammatory condition affecting the spine. Observational studies have suggested a heightened risk of urolithiasis in AS patients. However, due to the inherent limitations of observational research, the causal relationship between the two remains to be determined.
Objective: Utilizing the Mendelian randomization analysis approach, this study sought to explore the causal link between AS and urolithiasis.
Methods: Data from genome-wide association studies were employed for analysis. Mendelian randomization analyses were conducted using the IVW, MR-Egger, Weighted Median, and Weighted Mode methods. Heterogeneity tests, sensitivity analyses, and pleiotropy analyses were also performed.
Results: The causality between AS and urolithiasis was supported by the IVW (P=.02), Weighted Median (P=.006), and Weighted Mode (P=.01) methods. The MR-Egger method (P=.07) did not support this causal relationship, yet its directionality was consistent with the other three methods. None of the four analysis methods supported a reverse causal relationship between AS and urolithiasis.
Conclusion: Our study demonstrates a causal relationship between AS and urolithiasis, with no evidence of reverse causality. Given the increased risk of urolithiasis in AS patients, it is crucial to implement preventive strategies and early detection. Stone composition analysis should also be incorporated into clinical practice for these patients, as it can provide essential insights into the metabolic and genetic factors contributing to stone formation, thus improving diagnostic accuracy and treatment outcomes. Future studies are needed to further validate these findings and explore the detailed mechanisms involved.
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http://dx.doi.org/10.1016/j.fjurol.2024.102750 | DOI Listing |
J Health Popul Nutr
December 2024
School of Mathematical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Background: Foodborne illness is a significant public health concern, particularly in developing countries like Bangladesh. Young adults, aged 18-26 (including undergraduates and recent graduates), are especially vulnerable to the onset of unhealthy eating habits and nutritional imbalances as they begin living independently, often away from their families. This research aims to identify the risk factors associated with the knowledge, attitudes, and practices related to safe food handling among residential university students.
View Article and Find Full Text PDFJ Health Popul Nutr
December 2024
Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Background: The link between regional body fat distribution and overactive bladder (OAB) in prior epidemiological research has been uncertain. Our objective is to assess the relationship between increased regional body fat and the prevalence of OAB.
Methods: Within this analysis, 8,084 individuals aged 20 years and older were selected from NHANES surveys conducted from 2011 to 2018.
BMC Ophthalmol
December 2024
National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 3250027, China.
Objectives: To analyze the influence of daily activity-related factors associated with COVID-19 infection on the occurrence of acute angle closure (AAC).
Methods: A multicenter hospital-based study was conducted at 23 ophthalmic centers in 17 provincial-level regions across China to recruit patients with confirmed AAC during the post-lockdown time of COVID-19 (P-TOC) from Dec 7, 2022, to Jan 17, 2023, and three lockdown time of COVID-19 (TOC) periods, which included the TOC-2022 (Sep 7, 2022 - Dec 6, 2022), TOC-2021(Sep 7, 2021 - Jan 6, 2022) and TOC-2020 (Sep 7, 2020 - Jan 6, 2021). Patient information, including demographic, a questionnaire on daily activity changes during the AAC period, COVID-19 history, and eye examination results, was collected.
Implement Sci
December 2024
Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Background: A central goal of implementation science is to generate insights that allow evidence-based practices to be successfully applied across diverse settings. However, challenges often arise in preserving programs' effectiveness outside the context of their intervention development. We propose that qualitative data can inform generalizability via elucidating mechanisms of an intervention.
View Article and Find Full Text PDFParasit Vectors
December 2024
Global Health and Tropical Medicine- Institute of Hygiene and Tropical Medicine, NOVA University of Lisbon, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.
Background: Tick-borne rickettsioses (TBR) are emerging, neglected, zoonoses, caused by intracellular α-proteobacteria of the genus Rickettsia, that pose a growing public health concern. The aim of the present study was to evaluate rickettsial infections in questing ticks collected from four different ecological areas in mainland Portugal.
Methods: Over a two-year period, a total of 707 questing ticks were collected.
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