AI Article Synopsis
- Tissue repair after a heart injury is complex and affects all parts of the heart's tissue, including the extracellular matrix (ECM), which is crucial for structure and function.
- The ECM contains large proteins like collagen and elastin, as well as smaller matricellular proteins that help regulate cell interactions and responses.
- This review highlights the importance of matricellular proteins in maintaining heart structure and balancing the immune response, which is essential for overall heart health.
Article Abstract
Tissue repair after myocardial injury is a complex process involving changes in all aspects of the myocardial tissue, including the extracellular matrix (ECM). The ECM is composed of large structural proteins such as collagen and elastin and smaller proteins with major regulatory properties called matricellular proteins. Matricellular cell proteins exert their functions and elicit cellular responses by binding to structural proteins not limited to interactions with cell surface receptors, cytokines, or proteases. At the same time, matricellular proteins act as the "bridge" of information exchange between cells and ECM, maintaining the integrity of the cardiac structure and regulating the immune environment, which is a key factor in determining cardiac homeostasis. In this review, we present an overview of the identified matricellular proteins and summarize the current knowledge regarding their roles in maintaining cardiac homeostasis and regulating the immune system.
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| http://dx.doi.org/10.1016/j.biopha.2024.117463 | DOI Listing |
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