AI Article Synopsis
- Gastric cancer (GC) is a common and serious disease, prompting a need for new treatments due to the limitations of conventional methods like radiotherapy and chemotherapy.
- Traditional Chinese Medicine (TCM) is gaining attention for its low toxicity and ability to target multiple pathways, making it a potential alternative in GC therapy.
- Recent research shows that TCM can effectively combat GC by inhibiting tumor growth, inducing cell death, and enhancing the effectiveness of existing chemotherapy, suggesting a bright future for its use in treatment strategies.
Article Abstract
Background: Gastric cancer (GC) ranks as the fifth most prevalent malignancy worldwide. Conventional treatments, including radiotherapy and chemotherapy, often induce severe side effects and significant adverse reactions, and they may also result in drug resistance. Consequently, there is a critical need for the development of new therapeutic agents. Traditional Chinese Medicine (TCM) and natural products are being extensively researched due to their low toxicity, multi-targeted approaches, and diverse pathways. Scholars are increasingly focusing on identifying active anticancer components within TCM.
Purpose: This review aims to summarise research conducted over the past 14 years on the treatment of GC using TCM. The focus is on therapeutic targets, mechanisms, and efficacy of Chinese medicine and natural products, including monomer compounds, extracts or analogues, and active ingredients.
Methods: Relevant articles on TCM and GC were retrieved from PubMed using appropriate keywords. The collected articles were screened and classified according to the types of TCM, with an emphasis on the molecular mechanisms underlying the treatment of GC.
Results: The research on TCM indicates that TCM and natural products can effectively inhibit the metastasis, proliferation, and invasion of tumour cells. They can also induce apoptosis, autophagy and improve the chemosensitivity of drug-resistant cells. Additionally, injections derived from Chinese herbal medicine, when used as an adjunct to conventional chemotherapy, can significantly improve the prognosis of GC patients by reducing chemotherapy toxicity.
Conclusion: This review summarises the progress of TCM treatment of GC over the past 14 years, and discusses its therapeutic application of GC, which proves that TCM is a promising treatment strategy for GC in the future.
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| http://dx.doi.org/10.1016/j.phymed.2024.156003 | DOI Listing |
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