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Exercise intolerance and oxygen dynamics in nontuberculous mycobacteria with bronchiectasis. | LitMetric

AI Article Synopsis

  • * The study compared clinical data from 29 NTM-PD patients and 12 control participants, finding that NTM-PD patients had lower peak oxygen uptake and correlated changes in oxygen consumption during exercise with ventilatory variables, imaging findings, and cardiac pressure gradients.
  • * Results indicate that exertional oxygen consumption is linked to exercise tolerance and ventilatory efficiency in NTM-PD patients, highlighting the importance of tailoring rehabilitation programs to address their unique respiratory challenges like tachypnea and bronchiectasis.

Article Abstract

Background: Nontuberculous mycobacterial pulmonary disease (NTM-PD) patients often have exercise intolerance. Pulmonary rehabilitation (PR) to improve such patients' conditions is often not based on its exercise pathophysiology. We have reported that the oxygen consumption (ΔF) by expiratory gas analysis, i.e., the inspired-expired-expiratory mean oxygen concentration difference, is related to the minute ventilation-carbon dioxide output (V'-V')-slope and oxygen uptake (V') independent of the V'. The aim of this study was to investigate how ΔF is related to dynamic ventilatory variables, chest computed tomography (CT), and echocardiography findings in NTM-PD patients to understand their pathophysiological conditions.

Methods: Clinical data of NTM-PD patients with exertional dyspnea (n = 29) who underwent incremental exercise testing, chest CT, and echocardiography at the same time were compared with those of control participants (n = 12).

Results: In the NTM-PD group, 1) peak V' decreased (NTM-PD: 17.6 vs. controls: 28.7 mL⋅min⋅kg), and 2) ΔF at peak exercise was negatively correlated with respiratory frequency at peak exercise (correlation coefficient: r = -0.80, p < 0.0001), V'-V'-slope (r = -0.75, p < 0.0001), bronchiectasis CT score (r = -0.52, p = 0.0042), and the trans-tricuspid pressure gradient (r = -0.39, p = 0.0417), and positively correlated with peak V' (r = 0.71, p < 0.0001) and the body mass index (r = 0.42, p = 0.0217), but it was not correlated with V' at peak exercise and the cavity CT score.

Conclusions: Exertional oxygen consumption, independent of ventilatory ability, is associated with exercise tolerance and ventilatory efficiency, while being related to tachypnea and bronchiectasis rather than cavitation in NTM-PD patients. These findings may be useful in considering exercise physiology-based PR for NTM-PD patients with exertional dyspnea.

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Source
http://dx.doi.org/10.1016/j.resinv.2024.08.017DOI Listing

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