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Chromosome-level genome assembly of Tritrichomonas foetus, the causative agent of Bovine Trichomonosis. | LitMetric

Chromosome-level genome assembly of Tritrichomonas foetus, the causative agent of Bovine Trichomonosis.

Sci Data

Friedrich-Loeffler-Institut, Institut für Bakterielle Infektionen und Zoonosen (IBIZ), Naumburger Str. 96a, 07743, Jena, Germany.

Published: September 2024

AI Article Synopsis

  • Tritrichomonas foetus is a parasitic protist that causes bovine trichomonosis, significantly impacting the global livestock industry economically.
  • A new chromosome-level reference genome of T. foetus -KV-1 has been created using a combination of sequencing techniques, offering high-quality genomic data.
  • This genome, spanning 148 Mb and containing over 41,000 protein-coding genes, will aid future research in genomics, conservation, and taxonomy of this species.

Article Abstract

Tritrichomonas foetus is a parasitic protist responsible for bovine trichomonosis, a reproductive disease associated with significant economic burden to the livestock industry throughout the world. Here, we present a chromosome-level reference genome of T. foetus -KV-1 (ATCC 30924) using short-read (Illumina Miseq), long-read (Oxford Nanopore) and chromatin-linked (Hi-C) sequencing. This is the first chromosome-level genome of a parasitic protist of the order Tritrichomonadida and the second within the Parabasalia lineage, after Trichomonas vaginalis, the human-associated causative agent of the sexually transmitted infection in humans. Our constructed genome is 148 Mb in size, with a N50 length of the scaffolds of 22.9 Mb. The contigs are anchored in five super-scaffolds, corresponding to the expected five chromosomes of the species and covering 78% of the genome assembly. We predict 41,341 protein-coding genes, of which 95.10% have been functionally annotated. This high-quality genome assembly serves as a valuable reference genome for T. foetus to support future studies in functional genomics, genetic conservation and taxonomy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415386PMC
http://dx.doi.org/10.1038/s41597-024-03818-8DOI Listing

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