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Project HCV Connect: Using a County Surveillance Registry to Link Hepatitis C Virus-Infected Residents to Cure-Los Angeles County, April 2023 to March 2024.
J Public Health Manag Pract
March 2025
Author Affiliations: Keck School of Medicine,Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California (Dr Stafylis, Ms Hernandez-Tamayo, Mr Bhardwaj, Ms Shah, Ms Becerra, Ms Bruce, Ms Saini, Ms Saremi, Mr Thomas, Ms Manansala-Tan, Mr Vij, Ms Li, Mr Sudeep, Mr Gizamba, Mr Hosseini, Ms Navarro, Ms Ufret-Rivera, Dr Gounder, and Dr Klausner); and Los Angeles County Department of Public Health, Acute Communicable Disease Control, Viral Hepatitis Unit, Los Angeles, California (Ms Jewell).
Los Angeles County has a high prevalence of chronic hepatitis C virus (HCV) infection, but resources and infrastructure to notify and increase treatment uptake among county residents are absent. Through an innovative academic-public partnership, we developed a linkage-to-cure program utilizing the Department of Public Health's HCV surveillance registry. Case workers contacted reported cases via phone, to offer education, and treatment referral.
View Article and Find Full Text PDFAre resting-state network alterations in late-life depression related to synaptic density? Findings of a combined 11C-UCB-J PET and fMRI study.
Cereb Cortex
March 2025
Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
This study investigates the relationship between resting-state functional magnetic resonance imaging (rs-fMRI) topological properties and synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) synaptic density (SD) in late-life depression (LLD). 18 LLD patients and 33 healthy controls underwent rs-fMRI, 3D T1-weighted MRI, and 11C-UCB-J PET scans to assess SD. The rs-fMRI data were utilized to construct weighted networks for calculating four global topological metrics, including clustering coefficient, characteristic path length, global efficiency, and small-worldness, and six nodal metrics, including nodal clustering coefficient, nodal characteristic path length, nodal degree, nodal strength, local efficiency, and betweenness centrality.
View Article and Find Full Text PDFBone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways.
Aging Dis
March 2025
Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, 24252, Gangwon-do, Korea.
Age-related alterations in the skeletal system are linked to decreased bone mass, a reduction in bone strength and density, and an increased risk of fractures and osteoporosis. Therapeutics are desired to stimulate bone regeneration and restore imbalance in the bone remodeling process. Quercetin (Qu), a naturally occurring flavonoid, induces osteogenesis; however, its solubility, stability, and bioavailability limit its therapeutic use.
View Article and Find Full Text PDFIatrogenic Primary Hypothyroidism Associated With Sulfamethoxazole-Trimethoprim Treatment of Nocardiosis in a Cat.
J Vet Intern Med
March 2025
Animal Endocrine Clinic, New York, New York, USA.
A 9-year-old mixed breed cat with a history of recurrent ulcerated skin lesions was diagnosed with nocardiosis. Three months after initiating potentiated sulfonamide treatment, the cat developed goitrous hypothyroidism, characterized by palpable enlargement of both thyroid lobes, low serum concentrations of total thyroxine (T4) and free thyroxine (fT4), and high serum thyroid-stimulating hormone (TSH) concentration. Thyroid scintigraphy identified symmetrical enlargement of both thyroid lobes, with increased radionuclide (Tc-pertechnetate) uptake.
View Article and Find Full Text PDFCarboxymethyl Cellulose Surface Modification Alleviates the Toxicity of Fe-MOFs to Rice and Improves Iron Absorption.
Nanomaterials (Basel)
February 2025
Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China.
Iron-based metal-organic frameworks (Fe-MOFs) are widely used for agricultural chemical delivery due to their high loading capacity, and they also have the potential to provide essential iron for plant growth. Therefore, they hold significant promise for agricultural applications. Evaluating the plant biotoxicity of Fe-MOFs is crucial for optimizing their use in agriculture.
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