AI Article Synopsis
- - Biomolecular condensates are essentially droplets in cells that help organize proteins and RNA without needing membranes, playing a crucial role in various cellular functions.
- - Abnormal RNA behaviors, like being too abundant or misplaced, can disrupt these condensates and contribute to diseases such as cancer and neurological disorders.
- - The review explores how RNA influences condensate behaviors, the effects of dysregulation on disease, and potential new treatments that target RNA in these condensates, which could change how we approach complicated illnesses.
Article Abstract
Biomolecular condensates are dynamic membraneless organelles that compartmentalize proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert their effects on the cell by their roles in condensate formation and function. RNA abnormalities such as overexpression, modification, and mislocalization can lead to pathological condensate behaviors that drive various diseases, including cancer, neurological disorders, and infections. Here, we review RNA's role in condensate biology, describe the mechanisms of RNA-induced condensate dysregulation, note the implications for disease pathogenesis, and discuss novel therapeutic strategies. Emerging approaches to targeting RNA within condensates, including small molecules and RNA-based therapies that leverage the unique properties of condensates, may revolutionize treatment for complex diseases.
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| http://dx.doi.org/10.1016/j.chembiol.2024.08.009 | DOI Listing |
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