AI Article Synopsis
- The study investigates how historical redlining and current racial residential segregation affect leukocyte telomere length (LTL) in Black and Hispanic/Latinx individuals over a 10-year period.
- Using data from a health study involving 741 participants aged 45-84, researchers identified the impact of living in highly segregated neighborhoods on baseline LTL.
- Findings show that individuals in highly segregated neighborhoods had shorter baseline LTL compared to those in less segregated areas, emphasizing the need to address structural inequities linked to racial segregation.
Article Abstract
Background: We assessed the link between two manifestations of structural racism-historical redlining and contemporary racial residential segregation-and baseline and 10-year changes in leukocyte telomere length (LTL).
Methods: We used data on Black and Hispanic/Latinx participants from Exams I and V of the Multi-Ethnic Study of Atherosclerosis Stress Ancillary Study (N = 741, age range = 45-84 years). LTL was defined as the ratio of telomeric DNA to a single copy gene (T/S), and 10-year changes were adjusted for regression to the mean. We used 1930s Home Owners' Loan Corporation maps to assign three historical redlining grades (A&B: best/still desirable, C: declining, D: hazardous/redlined) to participants' neighborhoods (census-tracts) at baseline. The Getis-Ord G∗ statistic was used to evaluate census-tract level baseline residential segregation (low/moderate/high).
Results: In mixed-effects regression models accounting for neighborhood clustering, individual characteristics, and current neighborhood environments, those living in highly segregated Black neighborhoods had 0.08 shorter baseline LTL (95% CI: -0.13, -0.04), than those residing in the least segregated neighborhoods. We did not find a relationship between residing in segregated neighborhoods and 10-year LTL changes, and associations between residing in historically redlined neighborhoods and both baseline LTL and 10-year changes in LTL were null. Across discriminatory disinvestment trajectories examined, individuals residing in highly segregated but non-redlined neighborhoods had 0.6 shorter baseline LTL than individuals residing in non-redlined neighborhoods with low/moderate segregation (95% CI: -0.12, -0.01).
Conclusions: Our results highlight the impact of racial segregation on cellular aging and underscore the need to ameliorate structural inequities within segregated neighborhoods.
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| http://dx.doi.org/10.1016/j.socscimed.2024.117229 | DOI Listing |
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