The influence of sterol metabolism upon mutagenesis in Drosophila melanogaster was investigated using ecological-genetic yeast - drosophila system. Sterol deficiency in the organism of Drosophila was caused by using the strain of Saccharomyces cerevisiae 9-2P712 with a mutation in the nysr1 locus which blocks synthesis of ergosterol as a nutrition substrate for flies. It was concluded that maintenance of females on the mutant yeast strain causes an increase of radiation-induced X-chromosome loss in mature oocytes. Resistance of oocytes to X-ray irradiation is restored, reaching the control level, when 0,1% cholesterol solution in 10% ethanol is added to the yeast biomass. The possible membrane and hormonal mechanisms of elevation of induced aneuploidy and the role of sterol metabolism in ensuring resistance of insects to damaging factors are discussed.
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