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Exploring biological activities of novel Schiff bases derived from amlodipine and molecular modeling studies. | LitMetric

AI Article Synopsis

  • * New Schiff base derivatives of amlodipine were created to evaluate their potential for inhibiting urease and their antibacterial and antioxidant properties.
  • * Among the derivatives, 3g showed significant anti-hypertensive effects, while 3b, 3f, and 3g demonstrated the ability to inhibit urease, making them promising candidates for future research.

Article Abstract

Calcium channel antagonists are of considerable interest in treating elevated blood pressure and its pathologies. Schiff base derivatives of amlodipine were produced to check its urease inhibition potentials as well antibacterial and antioxidant activities. Structural illustration along with chemical characterization were achieved by spectral techniques (H NMR, FTIR, C NMR) and docking studies also performed. 3g displayed remarkable anti-hypertensive activity compared with parent drug. 3b, 3f and 3g showed urease inhibition potentials. These compounds can aid as lead for further investigations since they exhibited comparable or superior interactions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622768PMC
http://dx.doi.org/10.1080/17568919.2024.2401313DOI Listing

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