AI Article Synopsis
- Testing the biocompatibility of dental materials is crucial and this study focused on four specific materials: Mineral Trioxide Aggregate, Biodentine, Harvard BioCal-CAP, and Oxford ActiveCal PC.
- The evaluation used zebrafish embryos and larvae to assess survivability, hatching rates, and apoptosis through various toxicity tests.
- Results indicated that higher concentrations of these materials negatively affected survival and hatching, with Biodentine and Oxford ActiveCal PC showing better biocompatibility than Mineral Trioxide Aggregate.
Article Abstract
Testing the biocompatibility of commercially available dental materials is a major challenge in dental material science. In the present study, the biocompatibility of four commercially available dental materials Mineral Trioxide Aggregate, Biodentine, Harvard BioCal-CAP and Oxford ActiveCal PC was investigated. The biocompatibility analysis was performed on zebrafish embryos and larvae using standard toxicity tests such as survivability and hatching rates. Comparative toxicity analysis of toxicity was performed by measuring apoptosis using acridine orange dye and whole mount immunofluorescence methods on zebrafish larvae exposed to the dental materials at different dilutions. Toxicity analysis showed a significant decrease in survival and hatching rates with increasing concentration of exposed materials. The results of the apoptosis assay with acridine orange showed greater biocompatibility of Biodentine, Oxford ActiveCal PC, Harvard BioCal-CAP and Biodentine compared to MTA, which was concentration dependent. Consequently, this study has shown that showed resin-modified calcium silicates are more biocompatible than traditional calcium silicates.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414929 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0310996 | PLOS |
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