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Geometry of obstructed pathway regulates upstream navigational pattern of sperm population.
Lab Chip
January 2025
Department of Food Science and Technology, Cornell University, Ithaca, NY 14853, USA.
Sperm navigation through the complex microarchitecture of the fallopian tube is essential for successful fertilization. Spatiotemporal structural alteration due to folded epithelium or muscle contractions in the fallopian tube changes the geometry of the sperm pathways. The role of structural complexity in sperm navigational patterns has been investigated for single sperm cells but has not been fully addressed at the population level.
View Article and Find Full Text PDFGood Psychiatric Management of Borderline Personality Disorder and Co-Occurring Autism Spectrum Disorder.
Am J Psychother
January 2025
Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom, and Department of Psychiatry, University of East Anglia, Norwich, United Kingdom (Dudas); Spectrum Personality Disorder Service, Eastern Health, Richmond, Victoria, Australia (Cheney).
Borderline personality disorder has been estimated to occur among about 4% of those with autism spectrum disorder. This co-occurrence can escalate the challenges of treating either condition separately, and patients often face severe challenges in psychosocial and occupational functioning. Clinicians need guidance to manage a high degree of complexity, using standards of care and a synthesis of what is known so far, to navigate the currently limited armamentarium of clinical tools.
View Article and Find Full Text PDFChiral Locomotion Transitions of an Active Gel and Their Chemomechanical Origin.
J Am Chem Soc
January 2025
College of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116, Jiangsu, P.R. China.
Transitions between chiral rotational locomotion modes occur in a variety of active individuals and populations, such as sidewinders, self-propelled chiral droplets, and dense bacterial suspensions. Despite recent progress in the study of active matter, general principles governing rotational chiral transition remain elusive. Here, we study, experimentally and theoretically, rotational locomotion and its chiral transition in a 2D polyacrylamide (PAAm)-based BZ gel driven by Belousov-Zhabotinsky reaction-diffusion waves.
View Article and Find Full Text PDFA guide for active learning in synergistic drug discovery.
Sci Rep
January 2025
Laboratoire de Biophysique et Evolution, UMR CNRS-ESPCI 8231 Chimie Biologie Innovation, PSL University, Paris, France.
Synergistic drug combination screening is a promising strategy in drug discovery, but it involves navigating a costly and complex search space. While AI, particularly deep learning, has advanced synergy predictions, its effectiveness is limited by the low occurrence of synergistic drug pairs. Active learning, which integrates experimental testing into the learning process, has been proposed to address this challenge.
View Article and Find Full Text PDFA travelable area boundary dataset for visual navigation of field robots.
Sci Data
January 2025
School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210000, China.
Travelable area boundaries not only constrain the movement of field robots but also indicate alternative guiding routes for dynamic objects. Publicly available road boundary datasets have outlined boundaries by binary segmentation labels. However, hard post-processes have to be done to extract from detected boundaries further semantics including the shapes of the boundaries and guiding routes, which poses challenges to a real-time visual navigation system without detailed prior maps.
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