Ever since their introduction a decade ago, stable introns, a type of noncoding (nc)RNAs, are found to be key players in different important cellular processes acting through regulation of gene expression and feedback loops to maintain cellular homeostasis. Despite being commonly regarded as useless byproducts, recent studies in yeast suggested that stable introns are essential for cell survivability under starvation. In Drosophila, we found that a stable intron, sisR-1, has a direct effect in regulating mitochondrial dynamics during short-term fasting and subsequently improved overall oocyte quality. We speculated that the beneficial effects implicated by sisR-1 is through the activation of mitohormesis, an interesting phenomenon in mitochondrial biology. Mitohormesis is suggested to improve health span and lifespan of cells and organisms, but the involvement of ncRNAs is not well-documented. Here, we discuss the potential role of sisR-1 and other ncRNAs in activating mitohormesis and the possible applications in improving cellular and organismal health.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/bies.202400143 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Novel MSH6 exon 5-6 skipping variant in a Taiwanese family with Lynch syndrome: implications for genetic testing and cancer management.
Mol Cytogenet
March 2025
Department of Medical Research and Development, Chiayi Branch, Chang Gung Memorial Hospital Chiayi, Chiayi, 613, Taiwan.
Lynch syndrome is an autosomal dominant disorder predisposing individuals to colorectal and other cancers, primarily caused by variants in mismatch repair genes. This study describes a novel MSH6 variant affecting transcript structure in a Taiwanese family meeting the Amsterdam II criteria for Lynch syndrome. A 67-year-old male presented with jejunal adenocarcinoma and a strong family history of colorectal cancer.
View Article and Find Full Text PDFIntron-Derived Lariat RNAs Go Stable.
Wiley Interdiscip Rev RNA
March 2025
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
During pre-mRNA splicing, introns are removed by the spliceosome, and the flanking exons are ligated to form mature mRNA, which is subsequently translated into protein. Traditionally, intronic RNAs have been regarded as "junk", presumed to be degraded for nucleotide turnover. Notably, after debranching, some linearized lariat RNAs can be further processed into snoRNAs, miRNAs, and other long non-coding RNAs.
View Article and Find Full Text PDFNDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish.
Cell Death Discov
March 2025
Department of Medical Genetics, National Taiwan University Hospital, Taipei, 10041, Taiwan.
Complex I of the mitochondrial electron transfer chain is one of the largest membrane protein assemblies ever discovered. A patient carrying a homozygous NDUFB7 intronic mutation died within two months after birth due to cardiorespiratory defects, preventing further study. Here, we report another patient with compound heterozygous mutations in NDUFB7 who suffers from pons abnormality, lactic acidosis, prematurity, prenatal and postnatal growth deficiency, incomplete closure of the abdominal wall (ventral hernia), and a poorly functioning gastrointestinal tract (pseudo-obstruction).
View Article and Find Full Text PDFProperties of "Stable" Mosquito Cytochrome P450 Enzymes.
Insects
February 2025
Visiting Research Fellow, Department of Agricultural, Food and Environmental Sciences, Marche Polytechnic University, 60100 Ancona, Italy.
The use of insecticides is widespread in the control of debilitating mosquito-borne diseases. P450 enzymes (CYPs) play essential roles in mosquito physiological function but also in the enzymatic detoxification of xenobiotics. Broadly speaking, CYPs can be classified as "stable", meaning those that have no or very few paralogs, and "labile", constituting gene families with many paralogous members.
View Article and Find Full Text PDFA synthetic platform for developing recombinant adeno-associated virus type 8 producer cell lines.
Biotechnol Prog
February 2025
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota, USA.
Recombinant adeno-associated virus (rAAV) is one of the most widely used viral vectors for gene therapy. It is used in very high doses for the treatment of many diseases, making large-scale production for clinical applications challenging. We have established a synthetic biology-based platform to construct stable production cell lines, which can be induced to produce rAAV2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!