AI Article Synopsis
- Novel genome sequencing (GS) presents new chances to share results with healthy people, leading to a need for effective genetic counseling methods.
- A study with 466 participants used a genomic counseling model (GCM) that included a digital platform and webinars, showing that knowledge about genetics improved and decisional conflict (uncertainty in decision-making) decreased after the counseling.
- Most participants (86%) wanted to learn all GS findings after the counseling, indicating that the GCM effectively informed the general public and helped them feel more confident in decisions about genetic information.
Article Abstract
Purpose: Novel uses of genome sequencing (GS) present an opportunity for return of results to healthy individuals, prompting the need for scalable genetic counseling strategies. We evaluate the effectiveness of a genomic counseling model (GCM) and explore preferences for GS findings in the general population.
Methods: Participants (N = 466) completed GS and our GCM (digital genomics platform and group-based webinar) and indicated results preferences. Surveys were administered before (T0) and after (T1) GCM. Change in knowledge and decisional conflict (DC) were evaluated using paired-sample T and Wilcoxon tests. Factors influencing knowledge and results preferences were evaluated using linear and logistic regression models.
Results: Participants were 56% female, 58% white, and 53% ≥40 years of age. Mean knowledge scores increased (Limitations: 3.73 to 5.63; Benefits: 4.34 to 5.48, P < .0001), and DC decreased (-21.9, P < .0001) at T1 versus T0. Eighty-six percent of participants wished to learn all GS findings at T1 vs 78% at T0 (P < .0001). Older age, negative/mixed attitudes toward genetics and greater DC were associated with change in preferences after intervention.
Conclusion: In a population-based cohort undergoing GS interested in learning GS findings, our GCM increased knowledge and reduced DC, illustrating the GCM's potential effectiveness for GS counseling in the general population.
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| http://dx.doi.org/10.1016/j.gim.2024.101272 | DOI Listing |
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