AI Article Synopsis
- The study aimed to develop guidelines for antibiotic use during tooth extractions in cancer patients on denosumab, as there's a risk of medication-related osteonecrosis of the jaw (MRONJ).
- It analyzed 68 cancer patients' antibiotic administration practices and their correlation with MRONJ after tooth extractions over a 10-year period.
- Results showed a lot of inconsistency in antibiotic usage among hospitals, with amoxicillin being the most common; however, no significant link between MRONJ occurrence and the dosage or duration of amoxicillin was identified, suggesting a single preoperative dose may be sufficient.
Article Abstract
Purpose: Medication-related osteonecrosis of the jaw (MRONJ) occasionally occurs following tooth extractions in cancer patients receiving denosumab (Dmab). However, there are currently no established guidelines for perioperative antibiotic administration during tooth extraction in these patients. The primary objective was to develop guidelines for the dose and frequency of antibiotics during tooth extraction by investigating the correlation between the current status of antibiotic administration and the development of MRONJ.
Methods: This study included 68 cancer patients receiving high-dose Dmab who had tooth extractions between 2012 and 2022 at 10 hospitals. The relationship between the way of perioperative antibiotic administration and the development of MRONJ was analyzed. A value < .05 was considered significant.
Results: There was considerable variability across hospitals and surgeons regarding the type, dosage, and duration of antibiotic administration. Amoxicillin (AMPC) was the most commonly used antibiotic. Focusing exclusively on teeth extracted under AMPC administration, MRONJ developed in 21 out of 123 teeth (17.0%). No significant relationship was found between the development of MRONJ and the dosage or duration of perioperative AMPC administration.
Conclusion: Perioperative antibiotic administration alone may not be sufficient to prevent MRONJ. Therefore, a single preoperative dose is likely adequate for effective and appropriate AMPC administration. .
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11410737 | PMC |
| http://dx.doi.org/10.7759/cureus.67237 | DOI Listing |
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