Aims: Nerve conduction block using implanted electrodes is being used increasingly for clinical applications. Alternatively, non-invasive electrical nerve block would be beneficial for applications including pain block and muscle spasticity. Here we developed a novel means of non-invasive electrical nerve conduction blockade - transcutaneous direct current block (tDCB) - that produces direct block of nerve conduction.
Materials & Methods: In an rodent model, tDCB produced stable neuromotor blockade of sciatic nerve branches, dependent on stimulus parameters and electrode geometry.
Results: Partial-to-complete neuromotor block was achieved in all subjects using tDCB amplitudes at or below 20 mA, and complete block was achieved at amplitudes as low as 6 mA.
Conclusions: Our results reveal that neuromotor activity can be rapidly, reliably and reversibly blocked using tDCB.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412303 | PMC |
| http://dx.doi.org/10.2217/bem-2017-0011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta.
PLoS Genet
January 2025
Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Inositol 1,4,5-trisphosphate receptors (IP3R) mediate Ca2+ release from intracellular stores, contributing to complex regulation of numerous physiological responses. The involvement of the three IP3R genes (ITPR1, ITPR2 and ITPR3) in inherited human diseases has started to shed light on the essential roles of each receptor in different human tissues and cell types. Variants in the ITPR3 gene, which encodes IP3R3, have recently been found to cause demyelinating sensorimotor Charcot-Marie-Tooth neuropathy type 1J (CMT1J).
View Article and Find Full Text PDFOptical Imaging of Trigeminal Ganglion Excitation Evoked by Electrical Stimulation of the Trigeminal Nerve.
Cureus
December 2024
Division of Dental Anesthesiology, Faculty of Dentistry Graduate School of Medicine and Dental Sciences, Niigata University, Niigata, JPN.
Background There are many reports of anatomical and physiological studies on trigeminal ganglion neurons, but few studies have analyzed temporal changes in the excitation of the trigeminal ganglion. This study aimed to establish an experimental system for spatial and temporal imaging analysis of the excitatory dynamics of trigeminal ganglion cells evoked by stimulation of a peripheral branch of the trigeminal nerve. Methods After excision of the trigeminal ganglion with the inferior alveolar nerve (IAN) from Sprague Dawley rats (seven to nine weeks old), 400-µm-thick slices of the trigeminal ganglion with the IAN were prepared.
View Article and Find Full Text PDFProximal Median Nerve Conduction Velocity Slowing in Carpal Tunnel Syndrome: An Observational Retrospective Study.
Ann Neurosci
January 2025
Department of Physiology, AIIMS, Bathinda, Punjab, India.
Background: Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy, characterised by compression of the median nerve at the wrist. Traditional understanding views CTS as a distal compression issue, but recent evidence suggests potential proximal involvement.
Purpose: This study aimed to assess the prevalence of proximal median nerve conduction velocity (CV) slowing in CTS patients and examine its association with CTS severity.
Tibial Nerve injury in Medial Open Wedge-High Tibial Osteotomy - A Rare Complication with 14-Year Follow-Up.
J Orthop Case Rep
January 2025
Department of Orthopaedic Surgery, Murup Hospital, Changwon, South Korea.
Introduction: Medial open wedge-high tibial osteotomy (MOW-HTO) is a standard procedure for treating moderate varus arthritis in active adults. The reason for its popularity is having lesser complications than other types of HTO. However, it is not devoid of challenges.
View Article and Find Full Text PDFA Rare Case of Localized Pigmented Villonodular Synovitis of the Wrist presenting as Carpal Tunnel Syndrome.
J Orthop Case Rep
January 2025
Department of Orthopaedics, Bharatratna Dr. Babasaheb Ambedkar Municipal General Hospital, Mumbai, Maharashtra, India.
Introduction: A form of tenosynovial giant cell tumors (GCTs) that diffusely affects the soft tissue lining of joints and tendons is called pigmented villonodular synovitis or PVNS. About equal percentages of men and women are often affected, and it typically affects young individuals. The most typical sites of PVNS are the knee and ankle, making PVNS of the wrist a rare presentation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!