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| http://dx.doi.org/10.5588/ijtldopen.24.0124 | DOI Listing |
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Same-day molecular testing for targetable mutations in solid tumor cytopathology-The next frontier of the rapid on-site evaluation.
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Molecular Diagnostic Laboratory, Section of Cytopathology, Anatomic Pathology Department, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Introduction: This study aimed to assess the feasibility of implementing the Idylla system, an ultra-rapid, cartridge-based assay, as an extension of rapid on-site evaluation (ROSE) in cytology. The authors conducted a pilot validation study on specimens from non-small cell lung carcinoma, thyroid carcinoma, and melanoma, evaluating four assays designed to detect alterations in KRAS, EGFR, BRAF, gene fusions, and expression imbalances in ALK, ROS1, RET, NTRK1/2/3, and MET exon 14 skipping transcripts. They investigated the feasibility of providing accurate biomarker molecular testing results in a cytopathology laboratory within hours of specimen collection.
View Article and Find Full Text PDFCartridge-based sequencing for bedaquiline resistance detection from sputum.
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First molecular detection and characterization of Enterocytozoon bieneusi different genotypes in human patients from Italy.
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April 2024
Department of Clinical Sciences and Translational Medicine, University of "Tor Vergata", Rome 00133, Italy.
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- * Recent research in Italy presents the first molecular characterization of E. bieneusi in symptomatic patients, involving 410 faecal samples that tested positive using a molecular detection method.
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Rapid and reliable testing for clinically actionable EGFR mutations in non-small cell lung cancer using the Idylla platform: a real-world two-center experience in Greece.
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Laboratory of Translational Oncology, School of Medicine, University of Crete, Crete, Greece.
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View Article and Find Full Text PDFIntroduction: Individuals with human immunodeficiency virus (HIV) infection have an increased likelihood of developing tuberculosis (TB). The primary objective of this study was to compare the diagnostic accuracy of microscopy, culture, and the Xpert /Rifampicin (MTB/RIF) assay in the diagnosis of pulmonary TB in sputum samples of HIV-infected patients. The secondary objectives were to evaluate the sensitivity and specificity of these three methods along with a comparison of diagnostic approaches for detecting drug-resistant strains.
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