AI Article Synopsis
- Psoriasis is often linked with various health issues, including higher rates of obesity, which affects treatment choices and responses for affected individuals.
- This study aimed to examine differences in patient characteristics among those starting or continuing biologic therapies for psoriasis and to assess the use of topical treatments after one year of therapy.
- Findings revealed that younger patients with fewer instances of psoriatic arthritis were treated with ustekinumab, while most other patient factors remained consistent across different biologic treatments, indicating a need for more tailored treatment approaches.
Article Abstract
Background: Psoriasis is associated with several comorbidities and patients with psoriasis are more often obese than individuals without psoriasis. The excess disease burden is important to consider in choice of and response to treatment at the individual level.
Objective: To investigate whether patient characteristics differ across biologics for patients initiating biologic therapy and for patients still on biologic therapy after 1 year. Also, to quantify and compare the use of topical therapy among patients still on biologic therapy after 1 year.
Methods: This nationwide cohort study compared characteristics of patients prescribed adalimumab, etanercept, infliximab, secukinumab or ustekinumab for treatment of psoriasis by using data from the Danish registries.
Results: In the ustekinumab group, patients were younger and fewer had psoriatic arthritis. Patients treated with secukinumab and ustekinumab were less frequently co-treated with conventional systemics and topical therapy. All other patient characteristics such as sex, smoking and comorbidities other than psoriatic arthritis were similar across the biologic cohorts.
Conclusion: These results highlight the need to better understand which factors to consider when prescribing biologics to patients with psoriasis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361497 | PMC |
| http://dx.doi.org/10.1177/24755303241234292 | DOI Listing |
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