AI Article Synopsis
- Oral squamous cell carcinoma (OSCC) is a common head and neck cancer that is usually diagnosed late, leading to a poor outlook, and recent studies have suggested a link between OSCC and the presence of certain microorganisms in the tumors.
- A review of various studies found that bacteria associated with OSCC show different levels of abundance and diversity, and these bacteria can originate from sources such as oral plaque, saliva, and even the gut, influencing cancer-related processes in both positive and negative ways.
- The presence of these intralesional microbiota plays a crucial role in the progression of OSCC and related disorders, but challenges like inconsistent sampling methods and microbial identification highlight the need for further research to better understand their implications for treatment and
Article Abstract
Background: Oral squamous cell carcinoma (OSCC) is the predominant form of head and neck cancer, often diagnosed at late stages, resulting in a poor prognosis. Recent studies indicate a potential association between OSCC and microbial presence. Microorganisms have been identified in various tumors and lesions, including OSCC and oral potentially malignant disorders (OPMDs). Intralesional microbiota are considered important components of the tumor microenvironment (TME) and may contribute to carcinogenesis.
Methods: Sources were collected through thorough searches of databases PubMed and Embase. The review focused on microbial characteristics, potential origins, and their impact on cancer progression.
Results: Bacteria display varying abundance and diversity throughout the stages of OSCC and OPMDs. Intraleisional bacteria may have diverse sources, including not only oral plaque and saliva but also potentially the gut. Intralesional bacteria have both pro-carcinogenic and anti-carcinogenic effects, affecting processes like cell proliferation, invasion, and immune response.
Conclusions: Intralesional microbiota are crucial in OSCC and OPMDs, influencing both disease progression and treatments. Despite their significance, challenges like inconsistent sampling and microbial identification remain. Future research is required to fully understand their role and improve clinical applications.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413416 | PMC |
| http://dx.doi.org/10.1002/cam4.70209 | DOI Listing |
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