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| http://dx.doi.org/10.1016/j.jtha.2024.08.024 | DOI Listing |
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P2RY6 deletion promotes UVB-induced skin carcinogenesis by activating the PI3K/AKT signal pathway.
Cancer Sci
October 2024
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Our previous research has demonstrated that P2RY6 functions as an oncogene in DMBA/TPA-induced two-stage chemical skin carcinogenesis in mice. However, considering that human skin cancer is predominantly attributed to UV radiation from sunlight, additional investigations are needed to elucidate the role of P2RY6 in UVB-induced skin carcinogenesis. Surprisingly, we found that P2ry6-deficient mice exhibited marked promotion to UVB-induced skin papilloma formation compared with wild-type mice, suggesting its tumor-suppressive role in UVB-induced skin cancer.
View Article and Find Full Text PDFA new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice.
Elife
October 2024
College of Medical Laboratory Science, Guilin Medical University, Guangxi, China.
Article Synopsis
- Current cancer treatments struggle with tumor relapse, drug resistance, and inefficient outcomes because some tumor cells can evade the immune system.
- This study introduces a novel immunotherapy approach that uses serum-based antibodies from mice with a type of skin cancer (mCSCC) to target and reduce tumors.
- The experimental process involved isolating mCSCC cells, stimulating healthy mice to produce anti-tumor antibodies, and analyzing serum effects on tumor size and related proteins, showing promising results that warrant further investigation.
Resistance to tPA-induced fibrinolysis and activation of coagulation is present in autoimmune bullous diseases of the skin.
J Thromb Haemost
December 2024
Department of Dermatology, University of Nebraska Medical Center, Omaha, Nebraska, USA. Electronic address:
effect of hydroxyethyl starch on COVID-19 patients-associated hypofibrinolytic state.
Res Pract Thromb Haemost
February 2024
Laboratoire d'hématologie, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France.
Background: Despite systematic thromboprophylaxis, 30% of the COVID-19 patients in intensive care units develop thrombosis. This occurrence is associated with a hypofibrinolytic state measured by thromboelastometry when adding tissue plasminogen activator (tPA) to citrated whole blood for a further run for EXTEM (ROTEM).
Objectives: Because hydroxyethyl starches (HESs) affect fibrin polymerization, we have assessed its potential effect on tPA-induced fibrinolysis.
Synthesis and Biological Evaluation of Novel Fusidic Acid Derivatives as Two-in-One Agent with Potent Antibacterial and Anti-Inflammatory Activity.
Antibiotics (Basel)
July 2022
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Fusidic acid (FA), a narrow-spectrum antibiotics, is highly sensitive to various Gram-positive cocci associated with skin infections. It has outstanding antibacterial effects against certain Gram-positive bacteria whilst no cross-resistance with other antibiotics. Two series of FA derivatives were synthesized and their antibacterial activities were tested.
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