AI Article Synopsis
- - Gynecological cancers are increasingly prevalent and deadly worldwide, prompting public health concerns about their rising incidence and mortality rates.
- - PIWI-interacting RNAs (piRNAs) are small non-coding RNAs involved in regulating gene expression and have been found to be altered in various cancers, including gynecological types.
- - Emerging research suggests that abnormal piRNA expression could serve as diagnostic and prognostic markers, as well as potential therapeutic targets for gynecological cancers.
Article Abstract
Gynecological cancers are currently a major public health concern due to increase in incidence and mortality globally. PIWI-interacting RNA (piRNA) are small non-coding RNA consisting of 24-32 nucleotides that plays regulatory role by interacting with piwi family of protein. Recent studies have revealed that piRNAs are expressed in various kinds of human tissues and influences key signalling pathways at transcriptional and post transcriptional levels. Studies have also that suggested piRNA and PIWI proteins display frequently altered expression in several cancers. Recent research has indicated that abnormal expression of piRNA may play a significant role in development and progression of gynecological cancers. Clinical studies suggested that, abnormally expressed piRNAs may serve as diagnostic and prognostic marker, and as potential therapeutic targets in these cancers. In the present review article, we discussed the emerging role of piRNA and their utility as diagnostic and prognostic marker in gynecological cancers.
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| http://dx.doi.org/10.1016/j.lfs.2024.123065 | DOI Listing |
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