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Plasma transfusions in neonatal intensive care units: a prospective observational study.
Arch Dis Child Fetal Neonatal Ed
January 2025
Division of Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands
Objective: Despite lack of evidence supporting efficacy, prophylactic fresh frozen plasma and Octaplas transfusions may be administered to very preterm infants to reduce bleeding risk. International variation in plasma transfusion practices in neonatal intensive care units (NICUs) is poorly understood, therefore, we aimed to describe neonatal plasma transfusion practice in Europe.
Design: Prospective observational study.
Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study.
Lancet Reg Health Eur
December 2024
Sanquin Research, Sanquin Blood Supply Foundation, Amsterdam, the Netherlands.
Article Synopsis
- Platelet transfusions are given to preterm infants to prevent bleeding, but recent studies showed higher risks of mortality and major bleeding with transfusions at a higher platelet count threshold of 50 × 10/L compared to 25 × 10/L.
- A prospective observational study across 64 neonatal intensive care units in 22 European countries was conducted to assess current platelet transfusion practices, which included tracking transfusion rates, indications, and patient outcomes.
- The findings indicated that the lower transfusion threshold of 25 × 10/L is being adopted in practice, though there's considerable variation in transfusion volumes and rates, highlighting the need for further research to optimize these practices.
A comprehensive assessment tool of acute-phase rehabilitation is associated with clinical outcomes in patients after cardiovascular surgery.
Heart Vessels
September 2024
Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Article Synopsis
- The Perme intensive care unit (ICU) mobility score is evaluated for its effectiveness in predicting recovery outcomes for patients after cardiovascular surgery.
- After analyzing data from 249 patients, the study found that higher Perme Scores correlated with quicker recovery in mobility and better physical performance at discharge.
- Additionally, a higher Perme Score is linked to lower rates of death and unplanned readmissions, suggesting it may serve as a valuable tool for anticipating patient outcomes post-surgery.
Red Blood Cell Transfusion in European Neonatal Intensive Care Units, 2022 to 2023.
JAMA Netw Open
September 2024
Division of Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.
Importance: Red blood cell (RBC) transfusions are frequently administered to preterm infants born before 32 weeks of gestation in the neonatal intensive care unit (NICU). Two randomized clinical trials (Effects of Transfusion Thresholds on Neurocognitive Outcomes of Extremely Low-Birth-Weight Infants [ETTNO] and Transfusion of Prematures [TOP]) found that liberal RBC transfusion thresholds are nonsuperior to restrictive thresholds, but the extent to which these results have been integrated into clinical practice since publication in 2020 is unknown.
Objective: To describe neonatal RBC transfusion practice in Europe.
The Perme ICU Physical Competency Assessment - Response to Javaid et al.
Intensive Crit Care Nurs
February 2025
Universidad del Valle, Cali, Colombia.
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