A dual-response ratiometric near-infrared fluorescence probe based on cyanine platform for Cu detection and its imaging in vitro and vivo.

Spectrochim Acta A Mol Biomol Spectrosc

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China. Electronic address:

Published: January 2025

AI Article Synopsis

  • A new near-infrared fluorescent probe (NUST-Cy-1) has been developed that can detect copper (Cu) by showing different fluorescent responses at specific wavelengths (450 nm and 750 nm).
  • The probe exhibits large Stokes shifts and is highly sensitive, with a low detection limit of 1.4 μM specifically for copper.
  • Successful fluorescent imaging of copper in biological samples (both in vitro and in vivo) has been demonstrated using this probe.

Article Abstract

A near-infrared fluorescent probe (NUST-Cy-1) was disclosed here, which displays ratiometric and dual-channel response for Cu (λ = 450 nm, λ = 750 nm) with large Stokes shifts (143 nm, 375 nm, 75 nm respectively). This probe demonstrates high sensitivity with low detection limit (1.4 μM) and selectivity for Cu detection. Furthermore, fluorescent imaging of Cu in vitro and vivo were successfully achieved.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2024.125115DOI Listing

Publication Analysis

Top Keywords

imaging vitro
8
vitro vivo
8
dual-response ratiometric
4
ratiometric near-infrared
4
near-infrared fluorescence
4
fluorescence probe
4
probe based
4
based cyanine
4
cyanine platform
4
platform detection
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!