Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424927 | PMC |
| http://dx.doi.org/10.1016/j.ebiom.2024.105372 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pentraxin 3 promotes microglial M2 polarization and excitatory synapse formation in the hippocampus in depression.
Int Immunopharmacol
December 2024
Department of Radiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212001, China. Electronic address:
Depression is a prevalent mental illness that significantly impairs individuals' overall quality of life and physical well-being. However, the pathological mechanisms of depression remain unclear, and effective treatment strategies are urgently needed. Pentraxin 3 (PTX3), a long pentraxin protein, plays a significant role in various pathological conditions, including infections, immune responses, and tissue repair.
View Article and Find Full Text PDFPentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic toxicity via regulating ER stress and β-cell apoptosis.
Mol Cells
December 2024
Department of Pharmacology, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea; Senotherapy-based Metabolic Disease Control Research Center, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea. Electronic address:
The long pentraxin 3 (PTX3), a marker of inflammation, has been associated with cardiovascular disease, obesity, and metabolic syndrome. Recently, elevated serum PTX3 levels have been linked to type 2 diabetes in obese patients with nonalcoholic fatty liver disease. Diabetes mellitus is a metabolic syndrome characterized by hyperglycemia resulting from insufficient insulin secretion or action.
View Article and Find Full Text PDFGnRH antagonist protocol with hCG triggering ameliorates fertilization defect caused by failure of cumulus cell pentraxin-3 expression in unilateral endometriomas.
Eur Rev Med Pharmacol Sci
October 2024
Department of Obstetrics and Gynecology, Bahcesehir University, Goztepe Medicalpark Hospital, Istanbul, Turkey.
Objective: The aim of the study was to determine the expression pattern of long pentraxin 3 (PTX3) mRNA in cumulus cells (CCs) isolated from metaphase II oocytes of women with unilateral endometrioma undergoing controlled ovarian stimulation using a gonadotropin-releasing hormone antagonist (GnRHa) protocol.
Patients And Methods: A total of 60 CC samples, 30 from the affected ovary and 30 from the contralateral ovary, were collected from 12 patients with unilateral endometrioma who underwent flexible GnRHa protocol with recombinant human chorionic gonadotropin (rhCG) trigger. Thirty CC samples collected from the left ovary of 12 women with male factor infertility were used as external controls.
The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19.
EBioMedicine
October 2024
IRCCS Humanitas Research Hospital, 20089, Rozzano, Milan, Italy.
Interplay between host humoral pattern recognition molecules controls undue immune responses against Aspergillus fumigatus.
Nat Commun
August 2024
Institut Pasteur, Université Paris Cité, CNRS UMR2000, Unité Mycologie Moléculaire, Paris, France.
Article Synopsis
- PTX3 is a protective molecule that interacts with the fungus Aspergillus fumigatus in different ways, depending on the fungal form (germinating vs. dormant conidia).
- It recognizes germinating conidia through a specific polysaccharide and interacts with dormant conidia through weak binding with surface proteins, while other proteins (SP-D, C1q, C3b) enhance this interaction.
- PTX3 helps regulate inflammation by reducing the production of pro-inflammatory signals and increasing anti-inflammatory signals like IL-10 in immune responses related to aspergillosis and potentially serves as a biomarker for certain fungal infections.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!