Prurigo Nodularis Mechanisms and Current Management Options.

Cutis

Taylor A. Brown is from the Washington State University Elson S. Floyd College of Medicine, Spokane. Dr. Khachemoune is from the Department of Dermatology, Brooklyn VA Medical Center, New York, and SUNY Downstate Dermatology Service, Brooklyn.

Published: August 2024

AI Article Synopsis

  • Prurigo nodularis (PN) is a skin condition characterized by itchy lesions that can severely affect a person's quality of life.
  • Its symptoms can resemble those of other skin disorders, making diagnosis challenging and leading to potential misidentification.
  • The treatment landscape for moderate to severe PN has improved with the FDA-approved medication dupilumab, and the review discusses PN's underlying mechanisms, tissue characteristics, and treatment options.

Article Abstract

Prurigo nodularis (PN) manifests with highly pruritic lesions that negatively impact patient quality of life. Due to the variability in manifestation, hypertrophic lichen planus, pemphigoid nodularis, and neurotic excoriations tend to mimic PN. The pathophysiology of PN is believed to be due to interactions in the neural and immune pathways causing the release of proinflammatory and pruritogenic cytokines. Dermatologic and systemic conditions, including atopic dermatitis and chronic kidney disease, accompany PN diagnoses. Patients with moderate to severe or recalcitrant PN may benefit from dupilumab, the first medication approved by the US Food and Drug Administration (FDA) to treat PN. Here, we provide an updated review of PN with a focus on its pathophysiology, histologic findings, and current treatment options.

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Source
http://dx.doi.org/10.12788/cutis.1085DOI Listing

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