Predictive Value of the Naples Prognostic Score for Cardiovascular Outcomes in Patients With Chronic Kidney Disease Receiving Percutaneous Coronary Intervention.

Angiology

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Published: September 2024

AI Article Synopsis

  • The Naples prognostic score (NPS) is a new system designed to assess inflammation and nutrition in cancer patients, but its effectiveness in chronic kidney disease (CKD) patients after percutaneous coronary intervention (PCI) is still being studied.
  • A research study included 631 CKD patients who received PCI from 2019 to 2022, splitting them into low-risk and high-risk groups based on their NPS, with follow-ups conducted until November 2022 to measure Major Adverse Cardiac Events (MACE).
  • Results indicated that the NPS is better at predicting MACE than other assessment scores, and the high-risk group experienced more adverse events and had worse prognoses compared to the low-risk group.

Article Abstract

The Naples prognostic score (NPS) is a novel multidimensional inflammatory and nutritional assessment system in cancer patients. However, its significance in patients with chronic kidney disease (CKD) after percutaneous coronary intervention (PCI) remains unclear. The study has a single-center, retrospective design and included 631 patients with CKD who underwent index PCI between 2019 and 2022. All participants were divided into 2 groups according to the NPS (Low-risk group: = 209; High-risk group: = 422) and followed up until November 2022. The primary endpoint was Major Adverse Cardiac Events (MACE). NPS predicted MACE events better than other scores, besides, high-risk NPS with severe renal dysfunction (RD) group (MODEL 2) had superior MACE diagnostic efficiency than NPS high-risk group lonely. (NPS: AUC: 0.605, < .001; MODEL 2: AUC: 0.624, < .001, respectively). Kaplan-Meier survival analysis of two groups showed that high-risk group had higher incidence of MACE ( < .001). Meanwhile, high-risk group had higher MACE events [adjusted Hazard Ratio (aHR) 2.013, 95% CI 1.294, 3.132; = .002]. NPS is an independent prognostic factor for CKD patients undergoing index PCI before operation whose predictive value for survival prognosis is better than other nutritional and inflammatory indicators. Compared with low NPS, patients with high NPS have a relatively poor prognosis.

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Source
http://dx.doi.org/10.1177/00033197241285970DOI Listing

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