A single small molecule degrades numerous KRAS variants involved in cancer.
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Integrative analysis disclosing UQCRC1 as a potential prognostic and immunological biomarker of lung adenocarcinoma.
Pathol Res Pract
January 2025
Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510095, China. Electronic address:
Lung cancer is one of the most malignant cancers in the world. Approximately 40 % of lung cancer cases are lung adenocarcinoma (LUAD). Exploring new biomarkers was an urgent need for treatments of LUAD.
View Article and Find Full Text PDFThe differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A.
Cell Rep
December 2024
Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address:
Transcripts of the KRAS locus are alternatively spliced to generate two proteins, KRAS4A and KRAS4B, which differ in their membrane-targeting sequences. These splice variants have been conserved for more than 450 million years, suggesting non-overlapping functions driven by differential membrane association. Here, we use proximity labeling to map the differential interactomes of the KRAS splice variants.
View Article and Find Full Text PDFAnalysis of type 2 diabetes mellitus-related genes by constructing the pathway-based weighted network.
IET Syst Biol
December 2024
Department of Statistics, Modelling and Economics, UK Health Security Agency, London, UK.
Complex network is an effective approach to studying complex diseases, and provides another perspective for understanding their pathological mechanisms by illustrating the interactions between various factors of diseases. Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease involving genetic and environmental factors. By combining the complex network approach with biological data, this study constructs a pathway-based weighted network model of T2DM-related genes to explore the interrelationships between genes, here a weight is assigned to each edge in terms of the number of the same pathways in which the two nodes (genes) connected to the edge are involved.
View Article and Find Full Text PDF[Application of 9-gene panel in assisting fine needle aspiration cytology to diagnose thyroid cancer].
Zhonghua Zhong Liu Za Zhi
November 2024
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, China.
Article Synopsis
- The study investigates the effectiveness of a 9-gene panel for diagnosing thyroid nodules that have indeterminate cytological results, compared to traditional BRAF V600E single-gene detection.
- Researchers analyzed 579 thyroid nodule samples from patients, using next-generation sequencing to identify mutations in nine specific genes associated with cancer.
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Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes.
Commun Biol
September 2024
Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK.
Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a 'biological Proteolysis-Targeting Chimera' (bioPROTAC). Here we employ an analogous approach where the target protein is recruited directly to a human E2 ubiquitin-conjugating enzyme via an attached target binding domain.
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