AI Article Synopsis
- The study investigates how prematurity influences the methylation of the LINE-1 gene in neonates, with a focus on DNA samples taken at various days after birth.
- Researchers found that overall, premature infants had lower methylation levels at birth, but this difference reduced over time.
- Interestingly, extremely premature infants (born before 28 weeks) exhibited higher methylation levels, comparable to full-term babies, suggesting that prematurity significantly affects LINE-1 methylation patterns and highlighting the complexity of epigenetic effects.
Article Abstract
Promoter methylation of LINE-1 may be affected by prematurity, but there is little evidence in the literature. Blood from premature and full-term neonates on days 0, 5, 30 and 90 was analyzed for DNA methylation percentage in a promoter region of the LINE-1, after bisulfite conversion and pyrosequencing. Premature infants, as a whole, showed significantly lower methylation percentage at birth, but this difference diminished over time. However, the subgroup of extremely premature (<28 weeks gestational age) had higher methylation percentages, similar to full-term newborns. This research underscores the critical role of prematurity on the methylation pattern of LINE-1. These findings underline the complexity of epigenetic regulation in prematurity and emphasize the need for further studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486321 | PMC |
| http://dx.doi.org/10.1080/17501911.2024.2397329 | DOI Listing |
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