AI Article Synopsis
- Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) can be preceded by infections, and this study examines two MOGAD patients who also had latent syphilis infections.
- Clinical presentations included cervical myelitis and unilateral optic neuritis, with one patient also living with HIV and another with hepatitis B.
- The study found that patient antibodies reacted to both MOG and another unspecified antigen, suggesting a possible link between syphilis and autoimmune neuroinflammation, warranting further investigation into infectious triggers for MOGAD.
Article Abstract
Objectives: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is frequently preceded by infections. The underlying pathomechanism, however, remains poorly understood. Here, we present the clinical data of two MOGAD patients with concurrent syphilis infection and investigate the reactivity of patient-derived antibodies to MOG and ().
Methods: Longitudinal serum samples and soluble immunoglobulins in single B cell supernatants were measured for MOG reactivity by a live cell-based assay. Reactivity against was assessed by enzyme-linked immunosorbent assay.
Results: The two patients presented MOGAD and concurrent latent syphilis infection, manifesting as cervical myelitis and unilateral optic neuritis, respectively. The first patient had been living with HIV on antiretroviral therapy, and the second was concomitantly diagnosed with chronic hepatitis B infection. Upon screening of B cell supernatants, we identified reactivity to MOG or Notably, one B cell showed reactivity to both antigens.
Discussion: The coexistence of MOGAD diagnoses and latent syphilis, alongside the identification of antibody reactivity to MOG and , underscores the potential pathomechanistic link between syphilis infection and subsequent autoimmune neuroinflammation. Cross-reactivity between MOG and antibodies remains to be validated on a molecular level, and further characterization of infectious triggers associated with MOGAD is needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11408232 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1455355 | DOI Listing |
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