AI Article Synopsis
- * A follow-up colonoscopy after 5 months showed significant changes in the colon, now suggesting active ulcerative colitis rather than Crohn's disease.
- * Genetic testing revealed specific mutations, and treatment with colchicine led to complete clinical remission, indicating a possible link to familial Mediterranean fever and highlighting the importance of monitoring changes in colonic inflammation for accurate diagnosis.
Article Abstract
A 24-year-old woman was referred to our hospital with joint pain, fever, abdominal pain, and diarrhea. A colonoscopy revealed longitudinal ulcers with a cobblestone appearance throughout the entire colon, suggestive of Crohn's disease. However, treatment with 5-aminosalicylic acid, azathioprine, and infliximab failed to achieve clinical remission. A colonoscopy 5 months later revealed a diffusely spreading granular mucosa without visible vasculature, compatible with active ulcerative colitis. Based on these serial changes in colonic lesions, we tested the patient for gene mutations and found variants E148Q and L110P in exon 2. Administration of colchicine resulted in complete clinical remission. Our experience suggests that drastic changes in the features of colonic inflammation may be a clue to the diagnosis of enterocolitis associated with familial Mediterranean fever.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11408919 | PMC |
| http://dx.doi.org/10.1002/deo2.70013 | DOI Listing |
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