AI Article Synopsis
- Researchers successfully created heterofunctional polyester dendrimers up to the third generation, incorporating 21 bromine atoms, using a divergent growth method for the first time.
- They utilized direct azidation reactions to transform the bromide groups into clickable azide groups.
- This allows for the attachment of therapeutic and chemical agents to various sites on the dendrimers, enhancing their potential for biomedical use through various chemical reactions.
Article Abstract
Heterofunctional polyester dendrimers up to the third generation, containing 21 internally queued bromine atoms, have been successfully synthesized for the first time using a divergent growth approach. Direct azidation reactions enabled the conversion of the bromide groups to clickable azide pendant functionalities. Therapeutic and chemical moeities could then be coupled to the internal azide or bromide functionalities and external hydroxyl groups of the heterofunctional dendrimers through CuAAC, thiol-bromo click and esterification reactions, expanding their potential for biomedical applications.
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| http://dx.doi.org/10.1039/d4sm00849a | DOI Listing |
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