AI Article Synopsis
- PTX3 is an acute-phase reactant that increases during inflammation, and this study assessed its effectiveness as a marker for the severity of lower respiratory tract infections (LRTIs) in children.
- In a study involving 60 patients at Fayoum University Hospital, PTX3 levels were significantly correlated with factors like peak temperature, duration of hospital stay, and overall illness severity.
- The findings suggest that PTX3 can effectively indicate disease severity and prognosis, achieving a sensitivity of 93.3% and specificity of 70% for diagnosing LRTIs at a specific cut-off value.
Article Abstract
Background: Pentraxin 3 (PTX3) is an acute-phase reactant that is elevated in the plasma during inflammatory responses. We aimed to evaluate the utility of PTX3 as a clinical marker in children with lower respiratory tract infections (LRTIs) and the association between PTX3 and LRTIs severity.
Methods: We included 60 patients admitted to Fayoum University Hospital with LRTIs fulfilling the WHO criteria for diagnosing LRTIs. We collected data on peak temperature, respiratory rate, heart rate, oxygen saturation upon admission, and length of hospital stay. The complete blood count (CBC), C-reactive protein (CRP) level, and PTX3 were measured upon admission.
Results: PTX3 levels were significantly correlated with peak temperature, duration of hospital stay, the Pediatric Respiratory Severity Score (PRESS), total leucocytic count (TLC), CRP, and blood cultures.
Conclusion: PTX-3 represented the severity of the disease and predicted the prognosis. Pentraxin levels demonstrate a statistically significant sensitivity of (93.3%) and a specificity of (70%) at the cut-off value (of 8.84) with an area under the curve (90.7%) in the diagnosis of LRTIs.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411843 | PMC |
| http://dx.doi.org/10.1186/s13052-024-01735-5 | DOI Listing |
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