AI Article Synopsis
- A novel formulation of tedizolid phosphate (TZP) nanoparticle-loaded buccal films was developed to treat buccal wounds infected with Staphylococcus aureus.
- The optimal nanoparticle (NP) formulation was characterized and incorporated into mucoadhesive buccal films, demonstrating effective antibacterial properties in both in vitro and in vivo studies.
- The study found that the TZP-NP-loaded films significantly reduced bacterial counts and effectively inhibited S. aureus growth in wound samples, indicating their potential for long-lasting antibacterial treatment of buccal wounds.
Article Abstract
A novel tedizolid phosphate (TZP) nanoparticle (NP)-loaded buccal film formulation was developed for the treatment of buccal wounds infected with S. aureus. TZP-loaded chitosan NPs were produced and characterized to prepare this composite system. The optimum NP formulation was then loaded into mucoadhesive buccal films. The antibacterial effects of the obtained buccal films were evaluated by in vitro and in vivo studies. The optimum TZP-NP formulation (F8) had a particle size of 177.40 ± 2.97 nm and PDI and ZP values were 0.437 ± 0.002 and 33.9 ± 0.5, respectively. In antibacterial efficacy tests, the optimum NP containing buccal film formulation was used, which released approximately 90 % of TZP within 5 h. TZP-NP-loaded buccal films achieved a 3 log reduction in S. aureus within just 3 h. It was also administered to Wistar albino rats with S. aureus-infected buccal wounds. As a result of in vivo studies, a significant decrease in the number of S. aureus was detected in wound samples treated with TZP-NP-loaded buccal films. In addition, a complete inhibition of growth was observed on the fifth day of the film application. The current work suggested that the TZP-NP-loaded composite films could be promising candidates for effective and long-acting antibacterial treatment of buccal wounds.
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| http://dx.doi.org/10.1016/j.ijpharm.2024.124688 | DOI Listing |
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