This study aimed to identify and investigate the contributing factors influencing injury severity in single-vehicle run-off-road (ROR) crashes, which are known for their high severity. The primary objective was to analyze and compare the impact of these factors across three distinct vehicle classes: passenger cars, sport utility vehicles (SUVs), and pickups. A mixed logit model with heterogeneity in mean and variance was developed to analyze the injury severity outcomes in ROR crashes for the three vehicle classes. The model accounted for the potential variations in the impact of contributing factors across different vehicle types. The study revealed several significant variables consistently influencing injury severity across all three vehicle classes. These included driver age, alcohol or drug usage, seatbelt utilization, airbag deployment, higher travel speeds, and the vehicle model year post-2010. Notably, as driver age increased, the impact on changes in injury severity outcomes was more pronounced for pickup drivers compared to those operating passenger cars and SUVs. Among the common findings was the highly effective role of seatbelt usage in mitigating injury severity in ROR crashes. Additionally, passenger cars were associated with increased injury severity, particularly at relatively higher travel speeds exceeding 75 mph when contrasted with SUVs and pickups traveling between 61 and 75 mph. The study highlights the importance of considering vehicle class-specific factors in analyzing injury severity in ROR crashes. Recommendations include further in-depth investigations into distinct factors contributing to injury severity within each vehicle class and utilizing more extensive crash datasets to gain additional insights for enhancing road safety.
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http://dx.doi.org/10.1016/j.aap.2024.107786 | DOI Listing |
Nat Commun
December 2024
Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Penetrating orocutaneous or oropharyngeal fistulas (POFs), severe complications following unsuccessful oral or oropharyngeal reconstruction, remain complex clinical challenges due to lack of supportive tissue, contamination with saliva and chewed food, and dynamic oral environment. Here, we present a Janus hydrogel adhesive (JHA) with asymmetric functions on opposite sides fabricated via a facile surface enzyme-initiated polymerization (SEIP) approach, which self-entraps surface water and blood within an in-situ formed hydrogel layer (RL) to effectively bridge biological tissues with a supporting hydrogel (SL), achieving superior wet-adhesion and seamless wound plugging. The tough SL hydrogel interlocked with RL dissipates energy to withstand external mechanical stimuli from continuous oral motions like chewing and swallowing, thus reducing stress-induced damage.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Department of Nephrology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Mitochondrial dysfunction is a crucial event in acute kidney injury (AKI), leading to a metabolic shift toward glycolysis and increased lactate production. Lactylation, a posttranslational modification derived from lactate, plays a significant role in various cellular processes, yet its implications in AKI remain underexplored. Here, a marked increase in lactate levels and pan-Kla levels are observed in kidney tissue from AKI patients and mice, with pronounced lactylation activity in injured proximal tubular cells identified by single-cell RNA sequencing.
View Article and Find Full Text PDFJ Pediatr Hematol Oncol
January 2025
Departments of Pediatric Hematology.
Congenital thrombotic thrombocytopenic purpura (cTTP), which is associated with mutations in the gene for a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13), is a chronic and lifelong disease. The clinical course is variable. Regularly using ADAMTS13-containing products such as fresh frozen plasma (FFP) for long-term prophylaxis is the most important treatment to prevent thrombotic microangiopathy (TMA) episodes.
View Article and Find Full Text PDFDisabil Rehabil
December 2024
Department of Physiotherapy, Epworth HealthCare, Melbourne, Australia.
Purpose: To investigate the relationship between the distribution and severity of hypertonicity and spasticity on walking speed in people with neurological injuries.
Material/methods: This cross-sectional observation cohort study used the Modified Ashworth Scale (MAS) and Modified Tardieu Scale (MTS) to assess hypertonicity and spasticity of the gastrocnemius, soleus, hamstrings and quadriceps. Participants were classified as having a distal (gastrocnemius and/or soleus), proximal (hamstrings and/or quadriceps) or mixed distribution of hypertonicity or spasticity.
Clin J Sport Med
December 2024
Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan.
Objective: Compare time to recovery between initial and repeat concussions.
Design: Retrospective review of electronic medical record.
Setting: An interdisciplinary concussion clinic.
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