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Anti-gene oligonucleotide clamps invade dsDNA and downregulate expression.
Mol Ther Nucleic Acids
December 2024
Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred Nobels Allé 8, 14152 Huddinge, Stockholm, Sweden.
Anti-gene oligonucleotides belong to a group of therapeutic compounds, which, in contrast to antisense oligonucleotides, bind to DNA. Clamp anti-gene oligonucleotides bind through a double-stranded invasion mechanism. With two arms connected by a linker, they hybridize to one of the DNA strands forming Watson-Crick and Hoogsteen hydrogen bonds.
View Article and Find Full Text PDFDifferential regulatory effects of the N-terminal region in SYK-fusion kinases reveal unique activation-inducible nuclear translocation of ITK-SYK.
Sci Rep
January 2025
Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred Nobels Allé 8, Floor 8, 14152, Huddinge, Sweden.
ITK-SYK and TEL-SYK (also known as ETV6-SYK) are human tumor-causing chimeric proteins containing the kinase region of SYK, and the membrane-targeting, N-terminal, PH-TH domain-doublet of ITK or the dimerizing SAM-PNT domain of TEL, respectively. ITK-SYK causes peripheral T cell lymphoma, while TEL-SYK was reported in myelodysplastic syndrome. BTK is a kinase highly related to ITK and to further delineate the role of the N-terminus, we generated the corresponding fusion-kinase BTK-SYK.
View Article and Find Full Text PDFCoCoNest: A continuous structural connectivity-based nested family of parcellations of the human cerebral cortex.
Netw Neurosci
December 2024
Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Despite the widespread exploration and availability of parcellations for the functional connectome, parcellations designed for the structural connectome are comparatively limited. Current research suggests that there may be no single "correct" parcellation and that the human brain is intrinsically a multiresolution entity. In this work, we propose the Continuous Structural Connectivitity-based, Nested (CoCoNest) family of parcellations-a fully data-driven, multiresolution family of parcellations derived from structural connectome data.
View Article and Find Full Text PDFMonitoring and modulating cardiac bioelectricity: from Einthoven to End-user.
Europace
December 2024
Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
In 2024, we celebrate the 100th anniversary of Willem Einthoven receiving the Nobel Prize for his discovery of the mechanism of the electrocardiogram. Building on Einthoven's legacy, electrocardiography allows the monitoring of cardiac bioelectricity through solutions to the so-called forward and inverse problems. These solutions link local cardiac electrical signals with the morphology of the electrocardiogram, offering a reversible connection between the heart's electrical activity and its representation on the body surface.
View Article and Find Full Text PDFSurface-enhanced Raman spectroscopy: a half-century historical perspective.
Chem Soc Rev
December 2024
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, School of Electronic Science and Engineering, College of Environment and Ecology, State Key Laboratory of Marine Environmental Science, Department of Physics, iChEM, IKKEM, Xiamen University, Xiamen 361005, China.
Surface-enhanced Raman spectroscopy (SERS) has evolved significantly over fifty years into a powerful analytical technique. This review aims to achieve five main goals. (1) Providing a comprehensive history of SERS's discovery, its experimental and theoretical foundations, its connections to advances in nanoscience and plasmonics, and highlighting collective contributions of key pioneers.
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