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Phaeohyphomycosis Due to Verruconis gallopava: Rare Indolent Pulmonary Infection or Severe Cerebral Fungal Disease?
Mycopathologia
November 2024
Laboratoire de Parasitologie-Mycologie, Service de Parasitologie-Mycologie, AP-HP, Hôpital Saint-Louis, Université Paris-Cité, 1 Avenue Claude Vellefaux, 75010, Paris, France.
Introduction: Phaeohyphomycoses are uncommon and poorly understood opportunistic fungal infections, characterized by a wide spectrum of clinical manifestations ranging from localized skin lesions to disseminated disease. Most frequent genera are Alternaria, Cladophialophora, Exophiala or Curvularia. Less common ones, such as Verruconis gallopava, initially described as responsible of encephalitis of turkeys, pose significant challenges for diagnosis and treatment.
View Article and Find Full Text PDFA Rare Case of Intracranial Infection: Highlighting the Utility of Next-Generation Sequencing in Diagnosis.
Case Rep Transplant
September 2024
Division of Infectious Diseases Virginia Commonwealth University Health System, Richmond, Virginia 23298-0049, USA.
is a dematiaceous fungi and the most common cause of cerebral phaeohyphomycosis. Here, we report a rare case of cerebral ventriculitis with development of a cerebral abscess due to diagnosed by cell-free DNA next-generation sequencing. Noninvasive diagnostics led to earlier disease identification and initiation of antifungal therapy, which has the potential to reduce mortality in this highly fatal disease.
View Article and Find Full Text PDFCerebral Phaeohyphomycosis: An Unusual Case of Brain Abscess.
QJM
September 2024
Professor, Division of Clinical Infectious Diseases, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
evaluation of antifungal combinations against neurotropic dematiaceous fungi associated with primary cerebral phaeohyphomycosis.
Microbiol Spectr
August 2024
Department of Microbiology, ICMR-Advanced Mycology Diagnostic and Research Centre, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
Primary cerebral phaeohyphomycosis is a life-threatening disease caused by neurotropic dematiaceous fungi. At present, there are no consensus guidelines regarding optimal antifungal therapy in such cases. Generally, a combination of antifungal agents is recommended for treatment.
View Article and Find Full Text PDFFungal thalamic abscess caused by Rhinocladiella mackenziei in an immunocompetent patient.
Indian J Med Microbiol
June 2024
Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:
Cerebral phaeohyphomycosis (CP) stands as an exceedingly uncommon yet severe type of fungal infection affecting the central nervous system, attributable to dematiaceous fungi. Despite the patient's immune status, CP is associated with grave prognosis. In the present study, authors describe the first case of left thalamic fungal abscess due to Rhinocladiella mackenziei in an immunocompetent 39-year-old male patient in Jaipur, Rajasthan.
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