AI Article Synopsis
- MicroRNA sponges play a significant role in regulating both normal and disease-related biological processes, often working in groups or clusters.
- The text introduces a protocol using the R package miRSM 2.0 for identifying and analyzing these miRNA sponge modules in various data sets.
- This computational tool aims to enhance our understanding of how miRNA sponges are involved in diseases, with further details provided in the mentioned reference to Zhang et al.
Article Abstract
MicroRNA (miRNA) sponges synergistically modulate physiological and pathological processes in the form of modules or clusters. Here, we present a protocol for inferring and analyzing miRNA sponge modules in heterogeneous data using the R package miRSM 2.0. We describe steps for identifying gene modules, inferring miRNA sponge modules at multi-sample and single-sample levels, and performing modular analysis. From the perspective of computational biology, miRSM 2.0 has the potential to advance our understanding of the role of miRNA sponges in diseases. For complete details on the use and execution of this protocol, please refer to Zhang et al..
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424997 | PMC |
| http://dx.doi.org/10.1016/j.xpro.2024.103317 | DOI Listing |
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