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Intensive care supply and admission decisions.
J Health Econ
January 2025
Frontier Nursing University, United States of America.
Over 2005-2019, the number of neonatal intensive care units (NICUs) grew by 10%, and the number of NICU beds increased by 30%. This expansion in intensive care has raised concerns over unwarranted intensive care admissions. In this study, we examine whether the greater supply of NICUs causally raises admission rates.
View Article and Find Full Text PDFApplication and development of CRISPR technology in the secondary metabolic pathway of the active ingredients of phytopharmaceuticals.
Front Plant Sci
January 2025
College of Life Sciences, Northwest Agricultural and Forestry University, Yangling, Shaanxi, China.
As an efficient gene editing tool, the CRISPR/Cas9 system has been widely employed to investigate and regulate the biosynthetic pathways of active ingredients in medicinal plants. CRISPR technology holds significant potential for enhancing both the yield and quality of active ingredients in medicinal plants. By precisely regulating the expression of key enzymes and transcription factors, CRISPR technology not only deepens our understanding of secondary metabolic pathways in medicinal plants but also opens new avenues for drug development and the modernization of traditional Chinese medicine.
View Article and Find Full Text PDFSubway opening enables urban green development: Evidence from difference-in-differences and double dual machine learning methods.
J Environ Manage
January 2025
Center for China Fiscal Development, Central University of Finance and Economics, Beijing, 102206, China. Electronic address:
Urban rail transport is an important part of transport infrastructure, which is significant in empowering green-oriented urban development. However, few studies in the existing literature explore the effect of subway opening on urban green development. This paper uses Chinese data of 281 prefecture-level cities from 2008 to 2021 to explore the influence and mechanism of subway opening on urban green total factor productivity (GTFP) through the difference-in-differences (DID) and double dual machine learning (DDML) methods.
View Article and Find Full Text PDFAdvances in magnetic nanoparticles for molecular medicine.
Chem Commun (Camb)
January 2025
F. Joseph Halcomb III, M. D. Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40536, USA.
Magnetic nanoparticles (MNPs) are highly versatile nanomaterials in nanomedicine, owing to their diverse magnetic properties, which can be tailored through variations in size, shape, composition, and exposure to inductive magnetic fields. Over four decades of research have led to the clinical approval or ongoing trials of several MNP formulations, fueling continued innovation. Beyond traditional applications in drug delivery, imaging, and cancer hyperthermia, MNPs have increasingly advanced into molecular medicine.
View Article and Find Full Text PDFOptogenetics in medicine: innovations and therapeutic applications.
Curr Opin Biotechnol
January 2025
Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China; Wuhu Hospital, Health Science Center, East China Normal University, Wuhu 241001, China; Shanghai Academy of Natural Sciences, East China Normal University, Shanghai, China. Electronic address:
Optogenetics, an innovative approach integrating photonics and genetic engineering, enables precise control over molecular and cellular processes, opening up exciting new opportunities for precision-guided medicine. In this review, we highlight recent advances in optogenetic tools and their applications across a range of medical conditions, including vision restoration in retinitis pigmentosa via light-activated ion channels, precise immune response modulation in cancer immunotherapy, and blood glucose management in diabetes through controllable drug release. Optogenetics also plays a critical role in bioelectronic medicine, enabling seamless communication between electronic systems and biological tissues to enhance therapeutic precision.
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