Quantitative bacteriologic monitoring of bronchial secretions obtained by protected distal catheterism was performed in 60 critically ill patients under mechanical ventilation. A number of factors which have significant bearing on bacterial growth in the respiratory tract were demonstrated. A statistical correlation was found between aspiration pneumonia and presence of Enterobacteriaceae, as well as between hospital-acquired pneumonia and recovery of opportunistic pathogens. S. aureus was especially prevalent in patients under corticosteroids. Aminoglycoside treatments increased the frequency of Acinetobacter infections, whereas prevalence of S. aureus and P. aeruginosa appeared unrelated to the use of any specific antibiotic. The value of bacteriology on protected distal catheter bronchoscopy specimens is to allow accurate diagnosis of lower respiratory tract infections and provide guidelines for the choice of appropriate antibiotics.
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Front Pharmacol
January 2025
Department of Cardiology, Affiliated Changshu Hospital of Nantong University, Changshu, China.
Objective: This study aims to analyze the adverse drug events (ADEs) associated with tolvaptan in the Food and Drug Administration Adverse Event Reporting System database from the fourth quarter of 2009 to the second quarter of 2024.
Methods: After standardizing the data, various signal detection techniques, including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network, and Multi-Item Gamma Poisson Shrinker, were employed for analysis.
Results: Among the 7,486 ADE reports where tolvaptan was the primary suspected drug, a total of 196 preferred terms were identified, spanning 24 different system organ classes.
Cureus
December 2024
Anesthesiology, Centro Hospitalar Universitário de São João, Porto, PRT.
Background Lung resection is a complex surgical procedure performed in children to address various pulmonary conditions. The success of this surgical intervention in these patients lies in a multidisciplinary approach, with anesthetic management playing a critical role in ensuring the safety and efficacy of the procedure. Methods After approval by the local ethics committee, clinical data of 17 pediatric patients who underwent lung resection in our hospital from January 2012 to December 2022 were retrospectively analyzed.
View Article and Find Full Text PDFVet Res
January 2025
Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.
M. ovipneumoniae is a respiratory pathogen that can cause mild to moderate pneumonia and reduced productivity in domestic lambs. However, studies on both natural and experimental M.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine, Unidade Local de Saúde do Oeste - Hospital Distrital de Caldas da Rainha, Caldas da Rainha, PRT.
Sarcoidosis is a systemic granulomatous disease of unknown etiology, primarily affecting the lungs and the lymphatic system. Its diagnosis is challenging, and in many cases, it requires histopathological confirmation through the identification of non-caseating granulomas. The presented case illustrates its diagnostic complexity and highlights a rare, delayed complication associated with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).
View Article and Find Full Text PDFJ Intensive Care Med
January 2025
The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Introduction: Endotracheal tube (ETT) malpositioning can result in a myriad of complications. Daily chest radiographs (CXR) is the gold standard in monitoring these complications. Point-of-care transtracheal ultrasound (TTUS) is an emerging imaging modality for ETT positioning.
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