AI Article Synopsis
- - The study aimed to compare serum uric acid levels between patients treated with aspirin-ticagrelor and those treated with aspirin-clopidogrel, focusing on data from 2013 to 2020.
- - Out of 41,877 patients, results showed that the aspirin-ticagrelor group had significantly higher serum uric acid levels compared to the aspirin-clopidogrel group, with an odds ratio of 1.36.
- - The study concluded that it’s important to monitor uric acid levels in patients on aspirin-ticagrelor, particularly in those with kidney issues or taking diuretics.
Article Abstract
Objective: This study investigated whether serum uric acid levels are more elevated in the aspirin-ticagrelor group than in the aspirin-clopidogrel group. Materials and Materials and methods: We conducted a retrospective cohort study with patients between 2013 and 2020. Baseline and maximum serum uric acid levels within a 6-month follow-up period were analyzed to determine the increase in both groups.
Results: A total of 41,877 patients were enrolled. A statistically significant elevation of serum uric acid levels was found in the aspirin-ticagrelor group compared to the aspirin-clopidogrel group (odds ratio (OR; 95% confidence interval (CI)) = 1.36 (1.15 - 1.60), p < 0.001). Kidney dysfunction and diuretic use were also identified as risk factors for uric acid elevation.
Conclusion: Monitoring serum uric acid levels is recommended during aspirin-ticagrelor therapy, especially in patients with kidney dysfunction or those using diuretics.
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| http://dx.doi.org/10.5414/CP204606 | DOI Listing |
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