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http://dx.doi.org/10.1111/phpp.13000 | DOI Listing |
Alzheimer's disease (AD) is a common copathology in Lewy body dementia (LBD). The presence of AD is associated with a distinct clinical presentation, faster progression, and shorter survival in LBD. However, the relationship between-alpha synuclein and AD remains incompletely understood.
View Article and Find Full Text PDFFront Psychiatry
December 2024
Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Nat Chem Biol
January 2025
Boyce Thompson Institute, Cornell University, Ithaca, NY, USA.
Intricate coupling between metabolism and protein post-translational modifications (PTMs) has emerged as a fundamental aspect of cellular regulation. Recent studies demonstrate that protein modifications can originate from diverse metabolites, and that their regulation is closely tied to the cellular metabolic state. Here we explore recently uncovered PTMs, including the concept of 'modification of a modification', as well as associated feedback and feedforward regulatory mechanisms, in which modified proteins impact not only related metabolic pathways but also other signaling cascades affecting physiology and diseases.
View Article and Find Full Text PDFEur Radiol
January 2025
University of Toronto, Temerty Faculty of Medicine, Joint Department of Medical Imaging, Toronto, ON, Canada.
Surg Obes Relat Dis
December 2024
Jefferson Health, Philadelphia, Pennsylvania.
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