AI Article Synopsis
- * Diuretics, used for conditions like hypertension and heart failure, increase water and electrolyte excretion, and their development has evolved since the late 1700s, with a major breakthrough in 1957 when chlorothiazide was introduced.
- * Loop diuretics, including torsemide, furosemide, and ethacrynic acid, were developed in the 1950s and are powerful treatments for severe fluid overload, but they require careful monitoring due to potential side effects.
Article Abstract
The loop of Henle plays a key role in kidney function, especially in retaining solutes and concentrating urine. Diuretic agents, crucial for managing fluid overload and related conditions like hypertension and heart failure (HF), enhance water and electrolyte excretion. The history of diuretics dates back to 1775 with the discovery of , evolving significantly with the introduction of chlorothiazide in 1957, which revolutionized diuretic therapy. Loop diuretics, developed in the 1950s and including drugs like torsemide, furosemide, and ethacrynic acid, are potent agents acting on the loop of Henle. They are vital for treating severe fluid overload conditions and require careful monitoring to manage potential side effects.
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| http://dx.doi.org/10.59556/japi.72.0669 | DOI Listing |
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