AI Article Synopsis

  • * In a trial involving 40 patients with Grade 1 hypertension, LL-TS was effective in significantly lowering both systolic and diastolic blood pressure over three months compared to a control group.
  • * The study concluded that LL-TS is a promising approach for managing hypertension in young patients, but further research is necessary to confirm its safety and effectiveness.

Article Abstract

Background: Hypertension is a significant risk factor for cardiovascular and chronic kidney diseases. Its management in young people remains limited. Device-based therapies, such as low-level tragus stimulation (LL-TS), a noninvasive method that reduces sympathetic activity, have recently been explored for resistant hypertension.

Methods And Results: This trial involved patients with Grade 1 hypertension with no other medical history. LL-TS (20 Hz, 1 mA, 1 h/day) was applied for 3 months on the tragus (Intervention group [IG]) or earlobe (Control group [CG]). Blood pressure and outcomes were assessed at the first, second, and third months. Among 40 patients, 21 were in IG and 19 in CG. Baseline systolic blood pressure was similar between IG (142.62±8.18 mm Hg) and CG (143.00±8.61 mm Hg), =0.89. Post-LL-TS, systolic blood pressure showed significant reductions in IG compared with CG at the first (IG: 134.47±5.95 mm Hg, CG: 141.28±6.78 mm Hg, =0.002), second (IG: 132.50±7.51 mm Hg, CG: 140.62±7.15 mm Hg, =0.001), and third months (IG: 128.81±7.13 mm Hg, CG: 136.51±7.96 mm Hg, =0.003). diastolic blood pressure also differed significantly: first month (IG: 85.34±5.81 mm Hg, CG: 89.74±6.32 mm Hg, =0.03), second month (IG: 82.12±5.22 mm Hg, CG: 88.57±7.11 mm Hg, =0.002), and third month (IG: 80.71±5.96 mm Hg, CG: 87.55±5.26 mm Hg, =0.001). Heart rate was unchanged (>0.05). Only 0.01% of IG subjects reported site irritation, with no serious adverse events.

Conclusions: LL-TS led to significant blood pressure reductions in young patients with essential hypertension. Further larger trials are needed to confirm the safety and efficacy of LL-TS.

Registration: URL: https://www.chictr.org.cn/; Unique identifier: ChiCTR2000038448.

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.123.032269DOI Listing

Publication Analysis

Top Keywords

blood pressure
24
low-level tragus
8
tragus stimulation
8
third months
8
systolic blood
8
pressure reductions
8
blood
6
pressure
6
stimulation attenuates
4
attenuates blood
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!