The present work investigated the anxiolytic effect of the alkaloid fraction (AF II) from the root bark of . Female Swiss mice of 6 weeks old were used in this study. The animals were divided into three groups: 0.9% NaCl (vehicle group, s.c.), AF II (6 mg/kg, s.c.), and diazepam - DZP (5 mg/kg, s.c.). The light/dark box and elevated plus maze tests evaluated the animal anxiety. DMT was identified by the HPLC method. AF II showed significant anxiolytic effects in the two behavioural tests used.
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| http://dx.doi.org/10.1080/14786419.2024.2405875 | DOI Listing |
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