Org Biomol Chem
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.
Published: October 2024
The enantioselective synthesis of a fully functionalized cycloheptane core of the naturally occurring triterpenoid volvalerenol A, exhibiting pseudo- symmetry, was achieved. Enantioselective enzymatic desymmetrization (EED), asymmetric methallylation, and reductive ring opening of an cyclopropane overbred intermediate were the key reactions to access the cycloheptanone core. Further synthetic manipulations, a unique "MPV" (Meerwein-Ponndorf-Verley) type reductive ring-opening of an epoxide and other synthetic transformations, afforded two fully functionalized cycloheptane frameworks of the target molecule.
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http://dx.doi.org/10.1039/d4ob01110d | DOI Listing |
PLoS One
January 2025
Department of Cardiology, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
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College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin, China.
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View Article and Find Full Text PDFBrain Behav
January 2025
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
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Chairman and Professor of Ophthalmology, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Egypt.
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Chem Asian J
January 2025
Indian Institute of Science, Inorganic and Physical Chemistry, Indian Institute of Science, 560 012, Bangalore, INDIA.
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