AI Article Synopsis
- Large vessel vasculitis is a rare side effect associated with granulocyte colony-stimulating factor (G-CSF) therapy used in cancer treatment.
- A case study involved a patient with lung adenocarcinoma who received neoadjuvant chemotherapy and pegylated G-CSF, leading to the development of a fever after three cycles.
- Imaging tests showed a positive response to the chemotherapy but also indicated inflammation in large arteries, pointing to G-CSF-induced large vessel vasculitis as a possible diagnosis.
Article Abstract
Large vessel vasculitis is a known but rare side effect of granulocyte colony-stimulating factor (G-CSF) therapy. We report a case of adenocarcinoma lung with pleural infiltration and mediastinal lymphadenopathy, who was treated with neoadjuvant chemotherapy and pegylated G-CSF. After three cycles, he developed a fever. He underwent F-18 fludeoxyglucose (FDG) positron emission tomography computed tomography for fever of unkwnown origin evaluation, which revealed a response to chemotherapy along with the appearance of FDG avid mural thickening in a few large arteries, suggesting a diagnosis of G-CSF-induced large vessel vasculitis.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404730 | PMC |
| http://dx.doi.org/10.4103/ijnm.ijnm_138_23 | DOI Listing |
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